drug-discovery-biochemistry-conference-2017-keynote

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J Pharmacol Ther Res 2017 Volume 1 Issue 2

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academies

November 02-03, 2017 Chicago, USA

International Congress on

International Conference and Exhibition on

Drug Discovery, Designing and Development

Biochemistry, Molecular Biology: R&D

ntegralmembraneproteins provide the interfacebetweencells

and their environment. As doors andwindows of the cell, some

inside the cell also, they control essential processes with abject

precision. Therefore they offer many drug targets for control

of disease. In humans, the serotonin transporter, the glucose

transporter, andmany drug resistance drug exporters are prime

examples. In pathogenic organism’s essential transporters and

membrane viral restriction factors play essential roles that

if blocked or otherwise modulated provide new avenues to

therapeutics. Using several examples, I outline the newhorizons

available with integral membrane proteins as new technologies

have opened the way. Targeting by organic compounds as

drug leads and by antibody therapeutics are possible. Ways of

presenting purified membrane proteins for antibody selection

and maturation are presented. As new technologies are

developed the molecular structures of membrane proteins can

be obtained by X-ray and cryo electron microscopy methods. I

will present inroads into these processes.

Speaker Biography

Robert M Stroud is Professor of Biochemistry and Biophysics, University of California

in San Francisco. He focuses on the molecular basis for function of transmembrane

transporters and channels, and on structure-assisted drug discovery. He has contributed

to fundamental mechanisms of receptor proteins, lipid-protein interactions, enzymes

and protein-RNA recognition. He has obtained his BA and MA in Natural Sciences from

the University of Cambridge (UK), his PhD is from University of London (JD Bernal).

From a Postdoctoral and Professorship in Biological Chemistry at the California Institute

of Technology, he came to UCSF. His research involves structural determination

engineering and function of molecules and cells using X-ray crystallography, electron-

cryo microscopy, computational simulations, spectroscopy, super-resolution optical

microscopy. He is a Member of the National Academy of Sciences, a Fellow of the

American Academy of Arts and Sciences, a Fellow of the Royal Society of Medicine

(UK), Fellow and Former President of the US Biophysical Society.

Robert M Stroud

University of California at San Francisco, USA

Unlocking the membrane proteome: New opportunities for diagnostics and

therapeutics