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Case Reports in Surgery and Invasive Procedures | Volume 3

March 11-12, 2019 | London, UK

Biomarkers

Plastic and Cosmetic Surgery

International Conference on

Joint Event

Sirtuin1 deacetylated and stabilized DNA damage repair (XRCC1) to promote chemoresistance in cancer

Neelum Aziz Yousafzai, Hongchuan Jin

and

Xian Wang

Medical School of Zhejiang University, China

Chemoresistance is one of the most important challenges

in the clinical management of lung cancer. SIRT1 is a NAD

dependent protein deacetylase and implicated in diverse

cellular processes such as DNA damage repair, and cancer

progression. SIRT1 is upregulated in chemo resistant lung

cancer cells, genetic knockdown or chemical inhibition of SIRT1

reversed chemoresistance by enhancing DNA damage and

apoptosis activation, accompanied with XRCC1 degradation.

E3 ligase β-TrCP catalyzed the poly-ubiquitination of XRCC1

to promote its proteasome-dependent degradation. SIRT1

bound and deacetylated XRCC1 at lysine K260, K298 and

K431, preventing it from β-TrCP-dependent ubiquitination.

Mutations of these three lysine sites in XRCC1 abrogated the

interaction with β-TrCP and prolonged the half-life of XRCC1

protein. Here we describe SIRT1 confers chemoresistance

to lung cancer cells by deacetylating and stabilizing XRCC1.

Therefore, targeting SIRT1 might be a new strategy to manage

the chemoresistance of lung cancer, and probably other

cancers.

Speaker Biography

Neelum Aziz Yousafzai has completed her PhD in Oncology from Zhejiang University,

China. Her expertise in cancer diagnosis and therapy development approaches to

improving human health. Her open and contextual evaluation model based on responsive

constructivists creates new pathways for improving healthcare. She has great experience in

research, clinical, teaching and administration, both in hospital and education institutions.

She has published several research articles in well-known journals and delivered talks on

national and international forum. Her areas of interest are oncology, molecular biology,

immunology, biotechnology, pathology and genetics.