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allied
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Nov12-13, 2018 | Paris, France
Central Nervous System & Therapeutics
International Conference on
Journal of Neurology and Neurorehabilitation Research | Volume 3
Ciliary body melanoma with Optic Nerve Invasion and unusual tumoral pattern growth - A rare case
report
Florin-Vlad Ionita
1
, Radu Nastasie
1
, Adrian Dumitru
1,2
, Alina Popa-Cherecheanu
1,2
and
Mariana Costache
1,2
1
Universiy of Medicine and Pharmacy, Romania
2
Emergency University Hospital, Romania
T
he most common primary malignancy of the eye in white
adults is the uveal melanoma. Frequently, uveal melanoma
arises from choroid or iris. Ciliary body melanoma is a rare if
not exceptional subtype of uveal melanoma. In this paper we
will expose a case report about a multinodular growth pattern
of a ciliary body melanoma with optic nerv invasion and an
unusual tumour extraocular extension. The patient, age 80,
presented with permanent atrial fibrillation and no other
specific symptoms, the only inconvenience been a protrusion
of the tumour outside the eye globe. After clinical and imagistic
re-evaluation, the patient was diagnosed with multiple hepatic
and lung metastases. The patient was firstly diagnosed with
a small ciliary melanoma 10 years ago but at that time, she
refused surgical treatment.
After surgical excision, the specimen was sent for
histopathological examination to the Department of Pathology
of the Emergency University Hospital in Bucharest. Specimen
samples were fixed with 10% buffered formalin and were
processed by conventional histopathological methods using
paraffin embedding, sectioning and Hematoxylin–Eosin
staining. We have also performed immunohistochemical tests.
Light microscopy examination revealed a large-sized ciliary
body melanoma consisting of heavily pigment spindle and
epithelioid type cells (mixed cell type according to the modified
Calendar classification). The posterior chamber of the eye was
not affect but we observed multiple scattered malignant cells
within the optic nerve, a very unusual feature. This type of
ocular melanoma has a poor prognosis due to early metastases
but in this case, we emphasize the long-lasting evolution and
peculiar anterior growth pattern.
Speaker Biography
Florin-Vlad Ionita is student in the 4
th
year at the University of medicine and Pharmacy
“Carol Davila”, Bucharest, Romania. As a student his activity was oriented in the
neurosurgery domain but also In the other neurological fields. Starting with 2017 he
is the scientific coordinator at the “Walter E. Dandy” Neurosurgical Club, Bucharest,
Romania.
e:
vlad.ionita.1995@gmail.com