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September 23-24, 2019 | Prague, Czech Republic
2
nd
International Conference on
Palliative Care
Clinical Trials and Pharmacovigilance
Joint Event
&
Alopurinol-induced TEN and association with HLA B*58:01 in white patients
Fabrizzio P Saavedraa, Alberto S Garcíab, Enrique S Gonzálezb
and
Luis C L Romeroa
Hospital Universitari i Politecnic La Fe, Spain
W
e have read the article ‘A retrospective investigation
of Human Leucocytic Antigen (HLA). B*5801 in
hiperuricemia patients in a Han population of China’ by
Cheng et al. We would like to congratulate the authors for this
succesful publication and make some contributions. We have
had several cases in the intensive care section of our burn care
unit involvingWhite patients who developed Lyell’s syndrome
– all of them confirmed by biopsy – attributed to the use of
allopurinol. Although the correlation between HLA B*58:01
and toxic epidermal necrolysis (TEN) has been described in
Asian patients, we have begun to perform HLA genetic study
in patients presenting with Lyell’s síndrome associated with
allopurinol, in order to avoid treatment with xanthine oxidase
inhibitors in direct family of these, not only in Asian patients.
Given this fact, it might be advisable to set up a HLA B*58:01
screening program in all patients with allopurinolinduced
TEN, regardless of their race.
e
:
fabrizzio48@hotmail.comJ Clin Res Pharm, Volume:2
Journal of Clinical Research and Pharmacy | Volume 2