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Current Pediatric Research| Volume: 22
November 28-29, 2018 | Dubai, UAE
15
th
World Congress on
Pediatrics, Clinical Pediatrics and Nutrition
28
th
International Conference on
Nursing Practice
Joint Event
&
The effect of platelet transfusions on the mortality in Neonatal Intensive Care Unit
Tariq Rushdi Mohieldeen Alsafadi
Aziziah Maternity and Children Hospital, Saudi Arabia
Background:
Platelet transfusions (PTs) currently are the
only available treatment to thrombocytopenic neonates
at risk of bleeding. There is much evidence indicates that
increasing number of platelet transfusions administered to
thrombocytopenic neonates increasing the mortality rate, but
this association is controversial.
Aims:
The main aim of this study is to reveal if PTs increase the
mortality in Neonatal Intensive Care Unit (NICU). Secondary
outcomes include: 1. To identify most common causes and
hemorrhagicmanifestations of thrombocytopenic patients who
received platelets. 2. Platelets count andmean platelets volume
(MPV) changes after PTs. Design: Retrospective cohort study.
Setting: NICU at maternity and children hospital.
MaterialsandMethods:
Recordsreviewofallthrombocytopenic
neonates who received PTs at any time during NICU stay from
January 2006 till December 2014.
Statistical Analysis:
Binary logistic regression. Results: A total
of 756 PTs were given to 150 thrombocytopenic patients. PTs
didn’t significantly increase the mortality (OR: 1.067, CI: 0.967-
1.178). Giving platelets to thrombocytopenic neonates at risk
of bleeding with necrotizing enterocolitis (NEC) ≥2 significantly
decreased the mortality (OR: 0.16 CI: 0.033-0.85). Mechanical
ventilation >2 days because of respiratory failure decreased the
mortality (OR: 0.117, CI: 0.02-0.65). The most common cause
of thrombocytopenia that led to PT was proven sepsis. The
most common hemorrhagic manifestation was intraventricular
hemorrhage (IVH). The median increment of platelets count
after 162 PTs was 46.5. MPV after 126 PTs tended to decrease
by a median of 0.74 fL (femtolitre).
Conclusion:
Giving PTs to thrombocytopenic neonates at risk
of bleeding didn’t increase the mortality. PT may decrease the
mortality in thrombocytopenic neonates at risk of bleeding
with NEC ≥ 2.
Speaker Biography
Tariq Rushdi Mohieldeen Alsafadi has completed his neonatology fellowship at the
age of 32 years from king abdulaziz university, Saudi Arabia. He is a neonatology
consultant in East Jeddah hospital, KSA. He has 4 publications in international journals.
e:
tasafadi@hotmail.comTariq Rushdi Mohieldeen Alsafadi, Pediatrics and Clinical Pediatrics 2018
& Nursing Practice 2018, Volume 22
DOI: 10.4066/0971-9032-C2-006