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academies
Journal of Microbiology: Current Research | Volume 2
November 01-02, 2018 | London, UK
7
th
European
Clinical Microbiology Congress
4
th
International Conference on
Ophthalmology and Eye Disorder
Joint Event
&
Intravitreal administration of lysine-acetylsalicylate could be an effective approach to preserve retinal
vessels and to inhibit leukostasis in experimental diabetic retinopathy
Cristian Fernandez Martinez
Hospital General Universitario de Elche, Spain
Purpose:
We explore the effects of lysine acetylsalicylate
intravitreal injections to preserve retinal vessels and to inhibit
the presence of leukocytes in early stages of streptozotocin
induced diabetic retinopathy in rats.
Setting:
Inflammation has a central role in diabetic retinopathy
development. Oral administration of acetylsalicylic acid (AAS)
has reported therapeutic benefits in experimental diabetic
retinopathy but controversial in humans.
Methods:
Animals were assigned to two groups (intravitreal
lysine acetylsalicylate, untreated control) for comparison in
between. Intravitreal injections were administered twice (at
the weeks 4 and 8 from diabetes induction). Retinal ganglion
cell layer (GCL) and outer plexiform layer (OPL) were analysed
at central and peripheral retina sections.
Results:
Immunohistochemistry assay revealed a significant
preservation of central and peripheral retinal vessels in
both layers (P< 0.001) and a significant correlation between
leukocytes and preserved vessels in the GCL for both central
peripheral retina (P< 0.001) and in the OPL at the central retina
(P =0.015).
Conclusions:
Intravitreal use of lysine acetylsalicylate has
never been reported but its ability to reduce leukocytes and to
preserve retinal vessels in early stages of diabetic retinopathy
avoiding side effects associated to oral AAS makes it a tool that
deserves to be explored.
Speaker Biography
Cristian Fernandez Martinez is currently working in Hospital General Universitario de Elche,
Spain.
e:
cristianfermar@gmail.comCristian Fernandez Martinez, Clinical Microbiology and Eye 2018, Volume 2
DOI: 10.4066/2591-8036-C1-002