clinical-microbiology-eye-2018-keynote

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Notes:

allied

academies

Journal of Microbiology: Current Research | Volume 2

November 01-02, 2018 | London, UK

European

Clinical Microbiology Congress

International Conference on

Ophthalmology and Eye Disorder

Joint Event

ecently,

in vitro

model has been developed to study HIV-1

and influenza virus (Flu) co-infection based on HIV-1 sialo-

glycoprotein (Sgp) synthesis and virus replication in acute (MT2)

and chronically (H9/HTLVIIIB) double-infected cells. HIV-1 rep-

lication and gp120 concentration were quantified by specific

tests ( RT detection and gp120 Antigen Capture Assay, resp.)

The co-infection provoked desialylation of HIV Sgps, followed

by increased HIV replication. A hypothesis was outlined that

exogenous neuraminidase (NA) (Flu) changes the configuration

of HIV-1 gp120 through desialylation resulting in exposure of a

novel antigen.Monoclonal antibody to the principal neutralizing

determinant V3 but not the broadly reactive one against gp120

recognize and neutralize in concentration-dependent way the

epitope newly exposed on HIV-1 virion after flu infection. The

proposed model could contribute to better understanding of

pathogenesis of flu co-infection in people living with HIV.

In vivo

flu co-infection most probably leads to desialylation of both HIV

and the cell surface, thus facilitating the escape of HIV from im-

mune control. This fact coincides well with the increase of viral

load observed in HIV-infected persons with flu co-infection or

after flu vaccination. The findings described here reflect the in-

teraction between components of two viruses – NA of flu and

Sgps on HIV-1 without considering the cell surface. The hypoth-

esis is now extended to other exogenous agents containing NA

in HIV-infected people. Moreover, without HIV infection, it has

been reported that some sialylated glycoproteins can be desi-

alylated

in vivo

by interaction with endogenous cellular NAs,

thus changing their function.

Speaker Biography

Radka Argirova has many years of scientific and practical experience as a virologist,

especially in the field of HIV, retroviruses and oncogenic viruses. She graduated from

the Higher Medical Institute in Sofia in 1969. In 1973, she graduated from the Institute

of Virology “ Ivanovski “ in Moscow, where she obtained a degree in medical sciences

(Candidate of Medical Sciences). In 1987, she became an assoc. prof. in virology at the

Institute of General and Comparative Pathology of the Bulgarian Academy of Sciences.

Since 1994, he has been a doctor of medical sciences and since 1997, a professor of

virology. She is currently working in Tokuda Hospital.

radkaargirova@abv.bg

Radka Argirova

Tokuda Hospital, Bulgaria

Co-infection HIV/flu: From experimental model to individual health

Radka Argirova, Clinical Microbiology and Eye 2018, Volume 2

DOI: 10.4066/2591-8036-C1-001