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June 12-13, 2019 | Edinburgh, Scotland
8th European Clinical Microbiology and Immunology Congress
&
3rd World congress on Biotechnology
Joint Event
Microbiology: Current Research | Volume: 3 | ISSN: 2591-8036
Synthetic life: How to create new organisms from the computer to its industrial scaling
Francisco Cruz Rodríguez
Synbiomics Group, Mexico
E scherichia coli are a very organism important at
the biotechnological level due to its many relevant
physiological characteristics In addition to its fermentative
metabolism gives it a unique potential for industrial
biocatalysis. The application of recombinant DNA methods
for the expression of heterologous genes in E. coli can
improve the production of Metabolites and proteins of
industrial interest, allowing the introduction of native or
non-native metabolic pathways, for the production of a
wide range of chemical products. Metabolic engineering
has been in recent years responsible for providing strains
producers, however, in some cases; metabolic engineering
fails to supply good production strains. In recent decades,
systems biology and synthetic biology, have allowed us to
model and design organisms (synthetic organism) whose
phenotypes are evaluated from the computer and not
through trial and error (experimentally speaking, as it
comes doing with traditional techniques and methods)
due to the conception of what is known as Genomic Scale
Metabolic Models (Genome-scale metabolic models,
GEMs), which is the in silico representation, of all the
biochemical reactions that occur in an organism, coding
detailed and global information (genomic) on an organism
in a computational framework, with the objective of
predicting the cellular behavior of a given genotype, under
certain restrictions (rate of growth, production yield of the
product, carbon source, etc.). Offering a more rational,
systematic design. Modeling gen-protein in the computer
and genotype-phenotype, you can design production
strains in a more smart and efficient accelerating both the
yield and the industrial scaling of the production of the
metabolites synthesized by these synthetic organisms.
e:
Microbiol Curr Res, Volume 3
ISSN: 2591-8036
Notes: