8 / 8
Page 33
Notes:
allied
academies
Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
Joint Event
Chemistry and Organic Chemistry
Biomedicine & Pharmacotherapy
International Conference on
8
th
World Congress on
October 22-23, 2018 | Frankfurt, Germany
Use of polymer-based nanovectors in the immobilization of drugs
Tagiyev DB
Azerbaijan National Academy of Sciences, Azerbaijan
R
ecently, the researchers have focused on the synthesis of
nanogelles and drugs with the long-term effectiveness.
Use of polymers for this purposes plays the main role in the
delivery of drugs to the necessary organs among modern
methods. In this case, polymers as a matrix keep drugs for a
long time and help their gradually separation in the body. Thus,
drugs can not be released from the polymer until the polymer
macromolecules entering the required cell. In this regard, it is
reasonable using synthetic based polymer nanogels as vectors.
In the present work, polymer nanogells with new memory
were synthesized based on polyacrylic acid and poly-N-
vinylpyrrolidone to immobilize doxorubicin. The sorption
abilities of the obtained nanogels were studied and their
higher sorption capacity were found. By using such polymers
as vector, the therapeutic dose of doxorubicin in experimental
treatment of tumor diseases could be significantly reduced.
Time dependence on the release of gel from the immobilized
doxorubic in polymer nanogels at 37°C and at different p
H
was investigated. It was determined that, the release of
doxorubucin from nanogel at 37°C occurs in small portions
over a certain period of time and antibiotics keeps its
bioactivity for a long time. This is due to the absorption of
antibiotics both on the surface and volume of the polymer.
Inaddition, silver nanoparticleswere synthesized in themedium
of poly-N-vinylpyrrolidone and the complex of doxorubucin
with silver nanocomposite polymer was obtained. It was
determined that thedistributionof silver nanoparticles depends
on their presence in polymer environment. Thus, the poly-N-
vinylpyrrolidone /Ag0/ doxorubicin system remains stable at
p
H
= 5-8 for a long time and due to the protonation of poly-
N-vinylpyrrolidone in carbonyl groups at p
H
= 1-3 doxorubicin
loses its bioactivity regarding the breakdown of chemical
bond between Ag0/doxorubicin and poly-N-vinylpyrrolidone.
Speaker Biography
Tagiyev DB is the director/professor of Institute of Catalysis and Inorganic Chemistry,
Azerbaijan National Academy of Sciences. He has over 200 articles that have been cited
over 470 times, and his publication H-index is 13.
e:
dtagiyev@rambler.ruTagiyev DB, Chemistry and Biomedicine 2018, Volume 8
DOI: 10.4066/2249-622X-C4-011