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Page 29
April 15-16, 2019 | Milan, Italy
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Joint Event on &
PUBLIC HEALTH,
EPIDEMIOLOGY AND NUTRITION
2nd World Congress on
CELL AND GENE THERAPY
2nd International Conference on
Cell and Gene Therapy 2019 & Public Health Congress 2019 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 3
FUNCTIONAL DISORDERS, VASCULAR RISKS AND MALIGNANT DISEASES.
PREVENTION BY SUBJECTIVE LOWERING OF PREPRANDIAL BLOOD GLUCOSE (BY
PLANNING AND RECOGNIZING INITIAL HUNGER)
Mario Ciampolini
University of Florence, Italy
We recently described the training of the passage from scheduled to demandedmeals in infants and adults.
Reduction in energy intake was obtained by subjectively abolishing conditioned meals and by admin-
istering food only after demand by the infant or after hunger perception by the adult (Initial Hunger Meal
Pattern; IHMP). Conditioned meals were those scheduled and/or presented to the infant as well to the adult
by sight, smell, mentioning, gesturing or simply at a fixed mealtime. In contrast IHMP training consisted of
meal suspension and of feeding after the first infant’s demand or after an adult’s self-noticing arousal of hun-
ger. IHMP was checked by measuring mean blood glucose before three meals per day for a week (MBG) and
was associated with significant decreases in diary-reported energy-intake, MBG, glycated hemoglobin, body
weight, insulin AUC in glucose tolerance tests and in days with diarrhoea as compared to randomized control
subjects who maintained conditioned meals. Although generalized, conditioned eating is a modern aberra-
tion that is associated with development of insulin resistance and overall inflammation. These associations are
well demonstrated independently from the implicated mechanism. A state of overall subclinical inflammation
greatly increases cell and DNA replications and replication errors. After decades of DNA errors, oncogenic cells
arise and cumulate. A prevention of malignancies is possible by interrupting the development of conditioned
eating, insulin resistance and associated overall inflammation.
Mario Ciampolini, Arch Gen Intern Med 2019, Volume 3 | DOI: 10.4066/2591-7951-C2-026
Mario Ciampolini is a retired professor from University of Florence, Department of Paediatrics. He is the Emeritus member of the
society for the study of ingestive behavior and of ASN (American Society for Nutrition), member of the Academy of Sciences of India
Union. Two Children from Vanna Pastacaldi: Iacopo, orthopedic surgeon, director of a hospital in Sommerset (UK) and Lorenzo,
PhD in electronic engineering, currently in the management of ST Microelectronics (Grenoble, FR). He made humanistic studies
during the first seven years after graduation and wrote two Italian books: Human differences and a study on Renassaince. Human
differences he (born 1933) directed the gastroenterology Research Unit, a third level referral center in the department of Pediatrics
of the University of Florence (Meyer hospital) from 1965 to 2000. In Tuscany first he diagnosed celiac disease by theWatson capsule.
He worked at the Cornell University for a joined research with the University of Florence on energy expenditure in children. A long
term strategy was designed with Giuliano Parrini, prof. of physics (Florence, It), Andrea Giommi, prof. of statistics (Florence, It) and
Cutberto Garza, Boston College, Rector. Three students came from AmsterdamMedical Center to learn“Initial Hunger (IH)”. The unit
published 150 scientific articles, more than 50 in international Press. His main achievements are Hunger can be taught; and an initial
hunger meal pattern can be constructed (IHMP = Three IH arousals per day). IHMP decreases energy intake, mean pre-prandial BG,
body weight, insulin resistance and fecal energy loss. The sequence of 21 pre-prandial BG measurements in a week (Mean BG) is
stable and comparable through months in the single individual and stratified in population.
BIOGRAPHY