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Cancer Stem Cells 2019
Journal of Medical Oncology andTherapeutics | Volume 4
July 18-19, 2019 | Valencia, Spain
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
alliedacademies.comYEARS
CANCER STEM CELLS AND
ONCOLOGY RESEARCH
12
th
International Conference on
ACQUISITION AND AUGMENTATION OF CANCER STEM CELL-LIKE PROPERTIES IN
POLYMER THIN FILM-INDUCED TUMOUR SPHEROIDS
Sangyong Jon, Minsuk Choi, Seung JungYu, Yoonjung Choi, Yumi Lee, Junhyuk Song, Daeyoup Lee
and
Sung Gap Im
Korea Advanced Institute of Science and Technology, Korea
A
lthough cancer stem cells (CSCs) are thought to be responsible for tumour recurrence and resistance to
chemotherapy, CSC-related research and drug development have been hampered by the limited supply
of diverse, patient-derived CSCs. Here, author’s developed a functional polymer thin film (PTF) platform that
promotes conversion of cancer cells to highly tumorigenic three-dimensional (3D) spheroids without the use
of biochemical or genetic manipulations. Culturing various human cancer cells on the specific PTF, poly (2, 4,
6, 8-tetravinyl-2, 4, 6, 8-tetramethyl cyclotetrasiloxane) (pV4D4), gave rise to numerous multicellular tumour
spheroids within 24 hours, with high efficiency and reproducibility. Cancer cells in the resulting spheroids
showed an enormous increase in the expression of CSC-associated genes and acquired dramatically increased
drug resistance compared with 2D monolayer-cultured controls. These spheroids also showed greatly en-
hanced xenograft tumour forming ability and metastasis capacity in nude mice. By enabling the generation of
tumorigenic spheroids from diverse cancer cells, the surface platform described here will likely contribute to
CSC-related basic research and drug development.
Sangyong Jon et al., J Med Oncl Ther 2019, Volume 4
Sangyong Jon received his BS in 1993, MS in 1995 and PhD in 1999 from the Department of Chemistry of KAIST, Korea. Then he
moved to the US for his Post Doctorate career in the Department of Chemical Engineering at MIT. After returning to Korea, he
joined Gwangju Institute of Science and Technology (GIST) as an Assistant Professor of Life Sciences in 2004. He was promoted to
Associate Professor in 2007 and Professor in 2010. He is a Fellow of Korean Biochip Society and Korean Molecular Imaging Society.
He has published over 60 papers, numerous chapters, and 30 patents. He sits on the Editorial Board for two peer-reviewed journals
and is a regular reviewer for over 30 journals. His research interest lies at the interface of medicinal chemistry, biotechnology, and
biomaterials science.
syjon@kaist.ac.krBIOGRAPHY