cancer-stem-cells-2019-scientifictracks

Note:

Page 24

Cancer Stem Cells 2019

Journal of Medical Oncology andTherapeutics | Volume 4

July 18-19, 2019 | Valencia, Spain

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

CANCER STEM CELLS AND

ONCOLOGY RESEARCH

International Conference on

ACQUISITION AND AUGMENTATION OF CANCER STEM CELL-LIKE PROPERTIES IN

POLYMER THIN FILM-INDUCED TUMOUR SPHEROIDS

Sangyong Jon, Minsuk Choi, Seung JungYu, Yoonjung Choi, Yumi Lee, Junhyuk Song, Daeyoup Lee

and

Sung Gap Im

Korea Advanced Institute of Science and Technology, Korea

lthough cancer stem cells (CSCs) are thought to be responsible for tumour recurrence and resistance to

chemotherapy, CSC-related research and drug development have been hampered by the limited supply

of diverse, patient-derived CSCs. Here, author’s developed a functional polymer thin film (PTF) platform that

promotes conversion of cancer cells to highly tumorigenic three-dimensional (3D) spheroids without the use

of biochemical or genetic manipulations. Culturing various human cancer cells on the specific PTF, poly (2, 4,

6, 8-tetravinyl-2, 4, 6, 8-tetramethyl cyclotetrasiloxane) (pV4D4), gave rise to numerous multicellular tumour

spheroids within 24 hours, with high efficiency and reproducibility. Cancer cells in the resulting spheroids

showed an enormous increase in the expression of CSC-associated genes and acquired dramatically increased

drug resistance compared with 2D monolayer-cultured controls. These spheroids also showed greatly en-

hanced xenograft tumour forming ability and metastasis capacity in nude mice. By enabling the generation of

tumorigenic spheroids from diverse cancer cells, the surface platform described here will likely contribute to

CSC-related basic research and drug development.

Sangyong Jon et al., J Med Oncl Ther 2019, Volume 4

Sangyong Jon received his BS in 1993, MS in 1995 and PhD in 1999 from the Department of Chemistry of KAIST, Korea. Then he

moved to the US for his Post Doctorate career in the Department of Chemical Engineering at MIT. After returning to Korea, he

joined Gwangju Institute of Science and Technology (GIST) as an Assistant Professor of Life Sciences in 2004. He was promoted to

Associate Professor in 2007 and Professor in 2010. He is a Fellow of Korean Biochip Society and Korean Molecular Imaging Society.

He has published over 60 papers, numerous chapters, and 30 patents. He sits on the Editorial Board for two peer-reviewed journals

and is a regular reviewer for over 30 journals. His research interest lies at the interface of medicinal chemistry, biotechnology, and

biomaterials science.

BIOGRAPHY