5 / 5
Page 24
Notes:
allied
academies
February 25-26, 2019 | Paris, France
13
th
World Cancer Congress
Journal of Medical Oncology and Therapeutics | Volume 4
Anti-Cancer properties of the Foliose lichen,
Heterodermia diademata
(Taylor) Awasthi against Breast
Cancer cell lines
Jijo Francis
Sacred Heart College, India
N
ature has its own unique ways to solve her problems.
Natural products, especially phytochemicals, are becoming
an important area of research for drug discovery. Of late,
lichens, the consortium between algae and fungi, have drawn
a great deal of attention for their exceptional potential for
curing various diseases. Despite the advancement of science,
cancer treatment is still not satisfactory and effective. It might
reasonably be hypothesized that lichens could contribute to
cancer treatment by interfering with the development and/
or progression of cancer. In the present study, I explored the
anti-growth properties of the foliose lichen,
Heterodermia
diademata
(Taylor) Awasthi, collected from the Western Ghats
biodiversity hotspot, India. Preliminary investigation of the
cytotoxic potential of
H. diademata
was conducted on Daltons
Lymphoma Ascites (DLA) and Ehrlich’s Ascites Carcinoma
(EAC) in Tryphan Blue dye exclusion method. The anti-growth
effect was tested in human breast cancer cell line MDA-
MB-231 and normal cell line IEC-6 by MTT assay. Cell death
modes (apoptosis/necrosis) were morphologically assessed.
H. diademata
inhibited the growth in a dose dependent
manner up to a dose of 5 to 25µg/ml. IC50 in MDA MB-231
was estimated to be 20ug/mL. Whereas in case of IEC6 IC50
was found to be higher than 60 ug/mL indicative of its potent
cytotoxicity towards breast cancer cell. These results suggest
that
H. diademata
may induce cell death at very low doses thus
establishing its potential as a promising warrior for the crusade
against cancer.
Speaker Biography
Jijo Francis is doing his Post Graduation
(M.Sc.) in Zoology in Sacred Heart College
(Autonomous), Cochin, Kerala, India.
e:
jijothattil007@gmail.com