cancer-congress-2019-accepted-abstracts

Cancer Congress 2019

Journal of Cancer Immunology &Therapy | Volume 2

Page 20

July 22-23, 2019 | Brussels, Belgium

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

CANCER SCIENCE AND THERAPY

Global Congress on

MISSING CARCINOGENIC LINK BETWEEN BISPHENOL A (BPA) EXPOSURE AND BREAST

CANCER

Jalal N, Wei J, Jiang Y, Pathak JL, Surendranath AR

and

Chung CY

Tianjin University, China

isphenol A (BPA), used in the manufacture of clear plastic bottles and lining of food and beverage contain-

ers, has been implicated as a class 2B “Suspected” carcinogen and a teratogen by several countries. Within

the cell, BPA interacts with MAPK and NFκB pathways that can lead to several tumorigenic events. Previous

studies have either stopped at determining BPA induced DNA damage or cited the involvement of MAPK and

NFκB pathways and only high dose BPA exposures have been reported that present non-conclusive tumori-

genic evidence. These

in vitro

experiments demonstrate that low dose BPA not only causes single strand DNA

breaks (SSBs) at 9nM but also causes more error prone double strand breaks (DSBs) at 17nM in the target cell

lines. Author further used MCF-7 Human breast cancer and MCF-10A normal breast epithelial cell lines to com-

pare tumorigenic events of BPA exposure. Being metabolized quickly by the liver to form DNA adducts, it can

cause direct DNA damage and also act as an inhibitor of secretory pathway calcium ATPase1 (SPCA1). SPCA1

inhibition impacts the post-translational modification and intra-cellular transportation of insulin like growth

factor 1 receptor (IGF1R) to the surface. Collectively these events raise the

in vitro

risk of a normal cell line MCF-

10A to become tumorigenic.

J Cancer Immunol Ther 2019, Volume 2