breast-cancer-2017-scientifictracks-abstracts

Page 24

Notes:

allied

academies

J Med Oncl Ther 2017 | Volume 2 Issue 3

Breast Cancer

November 01-02, 2017 | Toronto, Canada

World Congress on

Nanoelectromechanical chip (NELMEC), an electromicrofluidic chip to diagnose epithelial and

mesenchymal breast circulating tumor cells from leukocytes based on Silicon nanograss electrodes

Mohammad Abdolahad

University of Tehran, Iran

n integrated nano-electromechanical chip (NELMEC)

has been developed for label free diagnosis of both

epithelial and mesenchymal circulating tumor cells (ECTCs

and MCTCs respectively) from white blood cells. This

nanoelectrically activated microfluidic chip fabricated by

silicon micromachining can trap large single cells (>12um)

at the opening of analysis microchannel arrays. The nature

of captured cells would be detected by assistance of silicon

nano grass (SiNG) electrodes patterned at the entrance of

the channels. Observable difference between the membrane

capacitance of ECTCs and MCTCs from WBCs (measured

by SiNG electrodes) is the key indication in our diagnosis

approach. NELMEC Chip not only solves the problem of size

overlapping between CTCs andWBCs but also detects MCTCs

without any markers and tagging processes as an important

problem in previously reported CTC detection systems. Great

conductivity of gold coated SiNG nanocontacts as well as

their safe penetration into the membrane of captured cells

facilitates precise and direct signal extraction to distinguish

the type of captured cells. The results achieved from

epithelial (MCF-7) and mesenchymal (MDA-MB231) breast

cancer cells circulated in unprocessed blood suggested the

significant diagnostic ability of NELEMC.

Speaker Biography

Mohammad Abdolahad has received his PhD in Nanoelectronic Engineering from

University of Tehran in 2013 and immediately joined to the university as Faculty

Member in school of electrical and computer engineering. During recent four years,

he published more than 25 papers and nine USA patents in the field of cancer

detection by nanoelectronic devices. He introduced CNT-ECIS, SiNW-ECIS and NELMEC

as new miniaturized systems for cancer diagnosis. He is now the Coordinator of

nanobioelectronic devices lab in UT and Adjoint Professor of Theran University of

Medical Sciences.