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J Med Oncl Ther 2017 | Volume 2 Issue 3
Breast Cancer
November 01-02, 2017 | Toronto, Canada
7
th
World Congress on
Nanoelectromechanical chip (NELMEC), an electromicrofluidic chip to diagnose epithelial and
mesenchymal breast circulating tumor cells from leukocytes based on Silicon nanograss electrodes
Mohammad Abdolahad
University of Tehran, Iran
A
n integrated nano-electromechanical chip (NELMEC)
has been developed for label free diagnosis of both
epithelial and mesenchymal circulating tumor cells (ECTCs
and MCTCs respectively) from white blood cells. This
nanoelectrically activated microfluidic chip fabricated by
silicon micromachining can trap large single cells (>12um)
at the opening of analysis microchannel arrays. The nature
of captured cells would be detected by assistance of silicon
nano grass (SiNG) electrodes patterned at the entrance of
the channels. Observable difference between the membrane
capacitance of ECTCs and MCTCs from WBCs (measured
by SiNG electrodes) is the key indication in our diagnosis
approach. NELMEC Chip not only solves the problem of size
overlapping between CTCs andWBCs but also detects MCTCs
without any markers and tagging processes as an important
problem in previously reported CTC detection systems. Great
conductivity of gold coated SiNG nanocontacts as well as
their safe penetration into the membrane of captured cells
facilitates precise and direct signal extraction to distinguish
the type of captured cells. The results achieved from
epithelial (MCF-7) and mesenchymal (MDA-MB231) breast
cancer cells circulated in unprocessed blood suggested the
significant diagnostic ability of NELEMC.
Speaker Biography
Mohammad Abdolahad has received his PhD in Nanoelectronic Engineering from
University of Tehran in 2013 and immediately joined to the university as Faculty
Member in school of electrical and computer engineering. During recent four years,
he published more than 25 papers and nine USA patents in the field of cancer
detection by nanoelectronic devices. He introduced CNT-ECIS, SiNW-ECIS and NELMEC
as new miniaturized systems for cancer diagnosis. He is now the Coordinator of
nanobioelectronic devices lab in UT and Adjoint Professor of Theran University of
Medical Sciences.
e:
m.abdolahad@ut.ac.ir