brain-disorder-mental-health-2018-keynote

2 / 5

Page 6
Notes:
allied
academies
Journal of Brain and Neurology| Volume: 2
November 05-06, 2018 | Edinburgh, Scotland
Brain Disorders and Therapeutics
Mental Heal th and Psychology
5th International Conference on
Joint Event
&
Central nervous system inflammatory demyelinating disease
(CIDD) encompasses a broad spectrum of disorders such as
multiple sclerosis (MS), acute disseminated encephalomyelitis
(ADEM) and neuromyelitis optica (NMO). Two cases of CIDD
with unusual clinical features are presented. In both cases,
histopathological examination played pivotal roles in the
anatomical diagnosis. Case 1 is a 51 year old female who
presented with headache, progressive aphasia and hemiparesis
without preceding infection or vaccination. Based on MRI
and negative oligoclonal bands in the CSF, a clinical diagnosis
of ADEM was made. However, brain biopsy of the affected
cerebral white matter revealed both pathological features
of ADEM and early stage of active MS including perivenular
demyelination, confluent plaque-like demyelination, and
subpial demyelination. Case 2 is an autopsied 73 year old
female who had been diagnosed as NMO at age 63 based on
typical clinical/radiological features and positive serum AQP4
antibody. One year before death, she was treated for an acute
myocardial infarction, and onemonth before death she suffered
a massive basal ganglia stroke diagnosed with CT. On autopsy,
the corresponding basal ganglia revealed large necrotic lesions
associatedwithseveralpathologicalsignaturesofNMOincluding
inflammatory cell infiltration, perivascular complement
deposition, and the presence of numerous corpora amylacea
phagocytosedby infiltratingmacrophages. These cases illustrate
the importance of neuropathological examination which
might be of interest in considering the pathogenesis of CIDDs.
Speaker Biography
Shinji Ohara is the Vice Director, Matsumoto Medical Center, Matsumoto Japan. He
graduatedfromTohokuUniversitySchoolofMedicine,Sendai,Japan,andfrompostdoctoral
course (Neuropathology) at Brain Research Institute, Niigata University, Niigata, Japan in
1986. He then completed Neurology Residency Program at Department of Neurology,
Washington University School of Medicine, St. Louis, MO, USA. Since 1995, he has served
as Director of Department of Neurology at Matsumoto Medical Center, Matsumoto, Japan
e:
Shinji Ohara
Matsumoto Medical Center, Japan
Central nervous system inflammatory demyelinating diseases with unusual clinical
features - Lessons learned from neuropathology