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July 01-02, 2019 | Paris, France
Brain Disorders and Therapeutics
6
th
International Conference on
Journal of Brain and Neurology | Volume: 03
Optoacoustics: An emerging, noninvasive theranostic modality for Brain Disorders
Rinat O Esenaliev
University of Texas Medical Branch, USA
W
e proposed to use optoacoustics for biomedical
applications and for more than 25 years have
been working on it starting from idea to clinical studies.
At present, optoacoustics is an emerging theranostic
modality. This novel technique is based on detection
and analysis of optoacoustic waves generated in tissues
by short optical pulses. We proposed many important
diagnostic, therapeutic, and theranostic applications of
this technology; developed and built optoacoustic systems;
and performed animal and clinical studies. Our diagnostic
applications include noninvasive transcranial mapping,
monitoring, and imaging for management of patients
with intracranial hematomas, stroke, neurodegenerative
disorders, and other neurological conditions. Here we
present an overview of our optoacoustic works from
ideas and basic science research to studies in tissues in
vitro and to animal and clinical studies. We developed
and built medical grade optoacoustic systems for early
detection of intracranial hematomas, mapping of cerebral
blood oxygenation, and detection of cerebral hypoxia. We
tested them in small and large animals (rats and sheep)
and then in humans: 1) healthy volunteers; 2) patients
with traumatic brain injury (TBI); 3) in neonates (both
term and premature); and 4) in fetuses during labor.
Recently, we proposed to use optoacoustics for therapy of
brain disorders and successfully tested it in rats with TBI.
The obtained animal and clinical data indicate that the
optoacoustic technique can be used for early diagnostics,
therapy, and theranostics of brain disorders. Research
support: multiple NIH grants including grants from NINDS,
NIBIB, and NICHD.
e:
riesenal@utmb.edu