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Biomaterials Congress 2019 Materials Science and Nanotechnology | Volume 3
Page 26
June 19-20, 2019 | Dublin, Ireland
BIOMATERIALS,
CELLULAR AND TISSUE ENGINEERING
3rd International Conference on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
DECELLULARIZED HYALINE CARTILAGE
GRAFT (DLHCG) FOR CARTILAGE REPAIR
I n this study, author has developed a continuous methodology to direct-
ly set up a scaffold-free macro-scaled three-dimensional living hyaline
cartilage graft (LhCG) with the aid of a biomaterial-based interim scaf-
folding system. The practical performance of decellularized LhCG (dLh-
CG) is evaluated in the knees of large animal models with full-thickness
chondral defects beyond critical sizes for six months. Hyaline cartilage
based neo-tissue fulfills the desired in situ reconstruction. LhCG is also
employed as an engineered biomimetic/pathological tissue platform for
anti-arthritis drug evaluation in vitro. Arthritic disease models are created
with LhCG by replicating the inflammatory environment of an arthritic
joint via co-culturing LhCG with lipopolysaccharide (LPS)-activated mac-
rophages, after which the accuracy of this model for in vitro drug-testing
was validated using a popularly applied non-steroidal anti-inflammatory
drug (NSAID). The results suggest that this new arthritic model is able
to adequately mimic the native arthritic cartilage and is suitable to be
used as an in vitro model for predicting native cartilage response to drug
treatment.
Dong-An Wang, Mater Sci Nanotechnol 2019, Volume 3
Dong-An Wang is a Professor of Biomedical En-
gineering in City University of Hong Kong. His
research interests include biomaterials, tissue
engineering and gene delivery. He has done sig-
nificant research work in his research areas and
published over 100 high quality journal papers
including nature materials, advanced functional
materials and biomaterials etc. He has been of-
ten invited as a theme Editor and Reviewer for a
number of top journals. He has been conferred
with various research/academic awards.
Dong-AnWang
City University of Hong Kong, China
BIOGRAPHY