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allied
academies
13
th
International Conference on
Alzheimers Disease and Dementia
November 25-26, 2019 | Frankfurt, Germany
Journal of Psychology and Cognition | Volume: 04
J Psychol Cognition, Volume: 04
A randomized double-blind clinical trial of Greek high phenolic early harvest extra
virgin olive oil of Chalkidiki variety in mild Cognitive Impairment: The MICOIL study
Magda Tsolaki
Aristotle University of Thessaloniki, Greece
A
double-blind randomized trial examined the effect of
Greek High phenolic Early Harvest extra virgin olive
oil (HP-EHVOO) and extra virgin olive oil with moderate
phenolic content (MP-EVOO) versus Mediterranean Diet
in 60 participants with Mild Cognitive Impairment (MCI)
for 12 months. An extensive neuropsychological battery
including global cognition, verbal fluency, Activities of
Daily Living (ADL), mood, attention, visuo-spatial ability
and memory was used for the assessment of the subjects
at baseline and after 12 months follow-up. Each participant
was randomized and allocated in one of three groups i) the
Group 1 received the HP-EVOO (50 mL/day), ii) the Group
2 received the MP-EVOO (50 mL/day), and iii) the Group 3
received only the Mediterranean Diet instructions which
followed also the other two groups. We found better post-
trial cognitive performance versus control in almost all
cognitive domains and significantly better performance
in ADAS-Cog, verbal fluency and memory tasks for
participants allocated to the Group 1. Also, participants
assigned to Group 2 showed improvement compared
to control Group 3, whereas Group 3 exhibited worse
performance in almost every neuropsychological test.
These findings suggest that a long-term intervention with
HP-EVOO or MP-EVOO was associated with improvement
in cognitive functions, and this improvement was found
compared with the Mediterranean Diet group.
e:
tsolakim1@gmail.com;