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Journal of Psychology and Cognition | Volume 4
May 13-14, 2019 | Prague, Czech Republic
Addiction Research and Therapy
2nd International Conference on
J Psychol Cognition, Volume 4
Naltrexone for Opioid dependence: Oral, Implantable and Injectable
Evgeny Krupitsky
First St Petersburg Pavlov State Medical University, Russia
Primary Purpose: The presentation will review results
of five randomized double-blind placebo controlled
randomized clinical trials of different drug formulations of
naltrexone we have been doing within the last 12 years:
Oral, implantable and injectable.
Experimental design:
1st study: Double blind placebo controlled randomized
clinical trial of oral naltrexone vs placebo. 2nd study:
Four cell double blind double dummy placebo controlled
randomized clinical trial of combination of naltrexone with
fluoxetine vs. naltrexone, fluoxetine and double placebo.
3rd study: Four cell double blind double dummy placebo
controlled randomized clinical trial of combination of
naltrexone with guanfacine vs. naltrexone, guanfacine and
double placebo. 4th study: Three cell double blind double
dummy placebo controlled randomized clinical trial of
naltrexone implant vs. oral naltrexone and double placebo
(oral and implantable). 5th study: Double blind placebo
controlled randomized clinical trial of injectable naltrexone
vs. placebo.
Summary of results: Oral naltrexone in Russia is more
effective for relapseprevention and abstinence stabilization
than placebo basically due to family involvement in
the control of compliance. Combining naltrexone with
antidepressants or guanfacine does not improve outcome
significantly. Long acting sustained release naltrexone
formulations (injectable and implantable) are substantially
more effective than oral naltrexone or placebo for relapse
prevention in opiate addicts as they make control of
compliance easier.
Conclusion: Extended release formulations of naltrexone are
the most effective abstinence-oriented pharmacotherapies
for opiate dependence.
Speaker Biography
EvgenyKrupitskyisavicedirectorforResearchandaChiefoftheDepartment
of Addictions at V.M. Bekhterev National Medical Research Center of
Psychiatry and Neurology in St.-Petersburg, and a Chief of the Laboratory
of Clinical Psychopharmacology of Addictions at St. Petersburg State Pavlov
Medical University, Russia. Since 2006 he also holds a position of Adjunct
Professor of Psychiatry at the Department of Psychiatry, University of
Pennsylvania. Major focus of his research is pharmacotherapy of drug and
alcoholdependence.Hereceivedseveralnationaland internationalawards
including European College of Neuropsychopharmacology Fellowship
Award (1997), Heffter Research Institute Award for Outstanding Research
in Hallucinogens (2000), National Institute Drug Abuse of National Institute
of Health (USA) Award for Excellence in International Leadership (2010),
and Galen Prize (Russia) (2016).
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