Hematology and Blood Disorders

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Renal Fibrosis

Fibrotic disorders are commonplace, take many forms and may be life-threatening. No better example of this exists than the progressive fibrosis that accompanies all chronic renal disease. Renal fibrosis may be a direct consequence of the kidney's limited capacity to regenerate after injury. Renal scarring leads to a progressive loss of renal function, ultimately resulting in end-stage kidney failure and a requirement for dialysis or kidney transplantation.

Although it manifests itself histologically as a rise in extracellular matrix, we all know that the histological appearance are often caused by a de novo synthesis of matrix (primarily collagen), or a disproportionate loss of renal parenchyma. In both cases the method depends on a resident mesenchymal cell, the so-called myofibroblast, and is independent of disease etiology. Potentially we will ameliorate fibrosis, either indirectly by modifying the environment the kidney functions in, or more directly by interfering with activation and performance of myofibroblasts.

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