Immunology Case Reports

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Neurosteroids

Neurosteroids, also identified as neuroactive steroids, are endogenous or exogenous steroids that quickly alter neuronal excitability over interaction with ligand-gated ion channels and additional cell surface receptors. The term neurosteroid was coined by the French physiologist Étienne-Émile Baulieu and refers to steroids made in the brain. The term, neuroactive steroid mentions to steroids that can be synthesized in the brain or are synthesized by an endocrine gland, that then reach the brain through the bloodstream and have effects on brain function.  neurosteroids have excitatory belongings on neurotransmission. They act as potent negative allosteric modulators of the GABAA receptor, weak positive allosteric modulators of the NMDA receptor, and/or agonists of the σ1 receptor, and mostly have antidepressant, anxiogenic, cognitive and memory-enhancing.

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