VEGF-A, a potential biomarker for systems medicine

doi:10.4066/biomedicalresearch-C8-023

VEGF-A, a potential biomarker for systems medicine

Joint Event on International Conference on Molecular Biology, Tissue Science and Regenerative Medicine & 4^th World Heart Congress
November 19-20, 2018 | Paris, France

Sofia Siest

University of Lorraine, France

Posters & Accepted Abstracts : Biomed Res

DOI: 10.4066/biomedicalresearch-C8-023

Abstract:

Vascular endothelial growth factorâA (VEGFâA) is implicated in angiogenesis, lymphangiogenesis, vascular permeability and haematopoiesis. It is associated with numerous pathologies including cardio-vascular diseases and several types of cancer. We specifically developed an integrative systems biology strategy for clinical improvement of this biomarker. A high heritability of this trait, 60% was estimated in the STANISLAS cohort giving us the needed arguments to continue for a deep characterization of the genetic component of VEGFâA levels. Therefore, we searched, by a Genome Wide Association Study (GWAS), the VEGFâA genetic variants and the inter-connexions of these biomarkers with other diseaseassociated molecules in healthy populations. Functional transcriptomic analyses were performed in peripheral blood mononuclear cells (PBMCs). Four polymorphisms (rs6921438, rs4416670, rs6993770, rs10738760) explaining ~50% of VEGFâA heritability were identified. These variants, directly or via gene x environment interactions had significant effects on HDL, LDL, TNF-a, IL-6, E selectin and ICAM-1 plasma levels. SNP rs6993770 was shown to increase VEGF121 mRNA levels and rs4416670 was associated with L-selectin expression. Recently, thanks to a meta-GWAS, we identified 6 additional rs further explaining VEGFâA levels variability and ongoing investigations focus on clinical implementation of the ââomicsâ determinants of this biomarker. Our integrative strategy illustrates an improved exemple to be applied for every biomarker with high heritability levels, consequently with potential interest in personalised medicine

Biography:

E-mail:

sophie.visvikis-siest@inserm.fr

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