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Understanding the effects of steroid hormone exposure on regulation of P53 and Bcl-2
International Conference on Molecular Biology and Genetic Engineering
November 07-08, 2019 | Melbourne, Australia
Wiley TS,J T Haraldsen
Wiley Compounding Systems, USA
Keynote : J Res Rep Genet
DOI: 10.35841/2591-7986-C1-001
Abstract:
Steroid hormones have been widely overlooked as controllers of gene expression. Through the mechanisms of gene expression (DNA methylation, histone methylation, and RNAi), we discuss the impact of normal reproductive templates on the pulsatility and amplitude of potential gene-regulating treatment protocols. By examining the interactions of estradiol (E2) and progesterone (P4) in women, we propose that changes in physiologic reproductive hormone templates of exposure and timing can affect fertility and even cancer through the silencing or amplification of gene products; such as P53 and Bcl-2 in women. We propose that uncontrolled hormone levels, due to aging and/or the environment, may be restored to a normal youthful template of gene expression through the fluctuating exogenous application of E2 and P4 that mimic the normal hormonal milieu of reproductive health. We hypothesize that this may lead to a lower risk of the chronic illnesses of aging and a better quality of life in patients suffering those conditions.
Biography:
Wiley TS has a B.A. from Webster University and is the CEO and Director of Wiley Compounding Systems, where she performs research in the area of theoretical medical understanding of the mechanisms of action for biological systems including gene regulation, hormonal mechanisms, and pharmaceutical dependence. She has published six papers and two books on the effects of hormone deregulation and its effects on genomics and other medical conditions.
E-mail: tswiley@hiredbrains.com
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