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Transcranial Doppler Ultrasound in stable Chronic Obstructive Pulmonary Disease
15th World Congress on DEMENTIA AND ALZHEIMER'S DISEASE
November 21, 2022 | Webinar
Roosevelt Santos Nunes
University of São Paulo, Brazil
Posters & Accepted Abstracts : J Clin Psychiatry Cog Psychol
Abstract:
Introduction: Cognitive impairment is highly prevalent in patients with Chronic Obstructive Pulmonary Disease (COPD) and may be a potential obstacle to the effectiveness of respiratory therapy. Patients with dementia have a pronounced disturbance in their cerebrovascular hemodynamics, such as cerebral hypoperfusion and increased downstream vascular resistance, and patients with COPD who has cognitive impairment also showed an altered cerebral perfusion. Objective: The present study aims to assess the presence of impaired cerebrovascular hemodynamic in stable COPD by means of transcranial doppler ultrasonography. Methods: This observational study was conducted among patients with stable COPD without known neurologic diseases. We performed Transcranial Doppler (TCD) sonography through the temporal window using a 1–5 MHz phased array ultrasound transducer with a TCD preset. Cerebrovascular hemodynamics were assessed by measuring mean flow velocities in the middle cerebral arteries (related to cerebral perfusion), resistance index (related to vascular resistance) and pulsatility index (related to vascular resistance). Results: Twelve consecutive patients (6 male; mean age, 61, 7 years) with stable COPD were assessed. The mean blood flow velocity in middle cerebral artery were decreased in 10 patients (mean flow velocity of 42,5 cm/s). The pulsatility index in middle cerebral artery were increased in 5 patients (mean pulsatility index of 1,03) and resistance index were normal in all patients (mean resistance index of 0,6). Conclusions: This study showed decreased cerebral perfusion but normal values of indexes of cerebral vascular resistance in stable COPD patients. References 1. Basile-Filho, Anibal et al. “The use of APACHE II, SOFA, SAPS 3, C-reactive protein/albumin ratio, and lactate to predict mortality of surgical critically ill patients: A retrospective cohort study.” Medicine vol. 98,26 (2019): e16204. doi:10.1097/ MD.0000000000016204 2. Nicolini, Edson A et al. “Could dysnatremias play a role as independent factors to predict mortality in surgical critically ill patients?.” Medicine Vol. 96,9 (2017): e6182. Doi:10.1097/ MD0000000000006182 3. Basile-Filho, Anibal et al. “The use of SAPS 3, SOFA, and Glasgow Coma Scale to predict mortality in patients with subarachnoid hemorrhage: A retrospective cohort study.” Medicine vol. 97,41 (2018): e12769. doi:10.1097/MD.0000000000012769
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