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THE RESULT OF CLINICAL TRIAL FOR THE NEW LONAL DRUG FOR HEPATOPROTECTIVE EFFECT IN PATIENT WITH FATTY LIVER DISEASE WITH CHRONIC HEPATITIS C
Joint Event on International Conference on SURGERY AND ANESTHESIA & 3rd International Conference on GASTROENTEROLOGY
November 12 -13 , 2018 | Rome , Italy
Ariunaa Z, Sarnai Ts, Erdenetsogt D and Badamjaw S
Research and Production Company of the Mong-Em, Mongolia
Posters & Accepted Abstracts : Case Rep Surg Invasive Proced
Abstract:
Introduction: Following researchers determined the Chronic hepatitis C virus infection which was 8,2% (Davaalkham.J et al, 2003), 9,6%(Takahashi.M et al, 2004), 9,8% (Tsatsralt-Od.B et al, 2006), 11,8% (Dagvadorj.Ya et al 2005) in Mongolia. As researchers noted that hepatitis C genotype 1 and 3 enable to be triglyceride accumulation for liver because it often occurs simultaneously fatty liver disease. Although many types of traditional medicine have been used for for hundreds years, their effectiveness of the therapy is relatively small with inadequate use of poorly understood in practice. These types of medicine’s storage, form, flavor are to improve which are prepared based on scientific studying, is to make the clinical trial of drug acts as easily use, emerged as one of the need for market. Therefore, our research team has made the clinical trial based on the chemical and pharmacological study of hepatoprotective effect for lonicera Altaica Pall fruit, an established clinical studies and producing new drugs. Results: Lonal drug decreases activation of syndrome hepatic cell cytolysis ALT (p=0.023), AST (p=0.037). Also decreases criteria of cholestasis syndrome such as indirect bilirubin (p=0.611), ALP (p=0.04), GGT (p=0.445). The Lonal medicine was taken during 21 days and comparing the results of lipid metabolism exchange before and after treatment, reduces TG (p=0,402), increases HDL (p=0.047). The participants have taken the Fibroscan analysis and liver biopsy. That was compared to determine before and after treatment such as steatosis and fibrosis degree. Before treatment degree of steatosis was S2: 278.4±75.3 dB/m and after treatment it was dropped from S1: 238.6±70.4 dB/m (p <0.05). And before treatment, such as fibrosis degree F2-3: 8.84 ± 2.2 kPa, after treatment it was decreased in F1-2: 7.18 ± 3.87 (p<0.01). In liver histology, comparing before and after treatment the results of liver cell inflammation-fibrosis area was reduced by 1,75 times and decreases hepatic steatosis degree (Strong fatty change was improved Mild fatty change). Conclusion: New lonal medicine is reducing activation syndrome hepatic cell cytolysis, cholestatic and some criteria of the metabolic syndrome in patient with fatty liver disease associated with chronic hepatitis C. Also new lonal medicine reduces the degree of liver steatosis and fibrosis by the analysis of Fibroscan and liver biopsy.
Biography:
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