+1 (202) 780-3397
The pharmocogenetics database of CYP2C19 variant in Healthy Thai population
36th International Conference on Immunology & Immunogenetics
August 13, 2021 | Webinar
Sadhu Wongsaroj, Atchara Srisodsai, Ph.D, Patompong Satapornpong, Ph.D
The Regents International School, Bangkok, Thailand (First author) MedCoach Institute, Bangkok, Thailand The division of general pharmacy practice, department of pharmaceutical care, College of Pharmacy, Rangsit University, Thailand (Corresponding author)
Scientific Tracks Abstracts : Immu Ca Rep
Abstract:
CY2C19 is a liver enzyme responsible for metabolizing clinical drugs such as: omeprazole, clopidogrel, phenytoin, proguanil, diazepam, citalopram, imipramine, amitriptyline and clomipramine. In previous studies, the variants of CYP2C19 can be used to predict the specific reaction a person might have after receiving medicine. The aim of this study was to investigate the variant of CYP2C19 genes and the allele distribution in the healthy Thai population. CYP2C19*2 (c.681G>A; rs4244285), CYP2C19*3 (c.636G>A; rs4986893), CYP2C19*17 (g.-806C>T; rs12248560) of 160 unrelated healthy Thai individuals were test using real-time PCR. The results show that the most common allele frequency was CYP2C19*1 with a percentage of 68.44%. The second most common allele frequency was CYP2C19*2 with a percentage of 23.75%. Lastly, CYP2C19*3 was found in only 4.69% and CYP2C19*17 with 3.13%. CYP2C19 metabolizer in the healthy sample consist of 4 phenotypes: Extensive metabolizers (EM) (CYP2C19*1/*1 of 45.00% and CYP2C19*2/*17 of 1.25%), the Intermediate metabolizers (IM) (CYP2C19*1/*2 of 34.38% and CYP2C19*1/*3 of 7.50%), the poor metabolizers (5.0% with CYP2C19*2/*2 and 1.88% with CYP2C19*2/*3 genotypes), and the Ultra rapid metabolizers (UM: 5.00% with CYP2C19*1/*17 genotype). The result shows that more than half of the participants have abnormal metabolism with only 46.25% of the participants having normal (extensive) metabolizers. A concerning 41.88% of participants are intermediate metabolizers. Thus, the database of CYP2C19 variant distribution in the healthy Thai population should be compared with other ethnicity to support precision medicine for screening prior before administration of medication to individuals. KEYWORDS: Thai population, CYP2C19 gene variant, Real-time PCR
Biography:
I am a year 12 student studying the IB diploma programn in the Regents International School Bangkok. My current interests are medicine and research; precisely pharmacogenetics. I hope to use this opportunity to strengthen my experience inorder to pursue my dream carrer of a doctor.
PDF HTML