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The influence of caffeine and nicotine co-administration in enhancing the power of physical activity against aluminum-induced Alzheimer’s disease in rats
13th World Congress on Dementia and Alzheimer’s Disease
September 16-17, 2019 | Paris, France
Azza A Ali, Hanan A Abd El-Samea, Amany Balah, Hebatalla I Ahmed, Ebtehal El-Demerdash
Al-Azhar University, Egypt
Posters & Accepted Abstracts : J Clin Psychiatry Cog Psychol
Abstract:
Background: Alzheimer’s disease (AD) is a
neurodegenerative disorder characterized clinically by
impairment of cognitive ability and memory. It represents
one of the most financially draining and health problem
diseases worldwide. Co-administration of caffeine and
nicotine can attenuate the impairment of memory and
cognitive decline associated with AD. Physical activities
promote neurogenesis, decrease inflammatory reaction
and eliminate oxidative stress.
Objective: The aim of the study is to evaluate the influence
of physical activity together with caffeine and nicotine coadministration
against aluminum-induced neurotoxicity
that mimics AD in rats, in addition to study their possible
mechanistic neuroprotective pathway.
Methods: Eight groups of rats were used and received
daily for four weeks: Saline for control, one group served
as model for AD and received (70 mg/kg, IP) aluminum
chloride.6H2O (AlCl3). The other six treated groups (three
of AD model and three without AlCl3) received combination
of caffeine (2.5mg/kg, IP) and nicotine (0.5 mg/kg, SC) or
exposed to physical activity (5 min swimming) or both of
them. Three behavioral experiments were performed:
Forced Swimming (FS) test, Morris Water Maze (MWM)
task and Conditioned-Avoidance and Learning (CAL)
test. Histopathological changes in the brain as well as
biochemical changes in acetyl cholinesterase (AChE),
β-amyloid protein (Aβ), oxidative stress markers (TAC,
SOD, MDA), monoamines (NE, DA, 5-HT), inflammatory
mediators (IL-6, TNF-α, NF-κB), brain derived neurotrophic
factor (BDNF), insulin-like growth factor-1 (IGF-1), glycogen
synthase kinase-3 beta (GSK-3β), β-catenin and Caspase-3
were also evaluated for all groups.
Results: Behavioral tests showed that co-administration
of caffeine and nicotine together with physical activity
have more pronounced protecting effect from learning
and memory impairment induced by AlCl3 than physical
activity alone. They also prevent neuronal degeneration in
the hippocampus induced by AlCl3 while physical activity
alone or co-administration of caffeine and nicotine still
showed mild degeneration in hippocampus. The marked
protection of both physical activity and co-administration
of caffeine and nicotine is confirmed also by the significant
improvement in biochemical parameters in brain tissue
than using each of them alone.
Conclusion: Physical activity together with coadministration
of caffeine and nicotine can reduce the
risk of neuronal degeneration in the hippocampus and
attenuate the impairment of learning and memory
associated with AD in rats.
Biography:
Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology from Faculty of Pharmacy, Cairo University, Egypt. She developed research line of behavioral pharmacology in Egypt and participated as Advisory Board Member of the Arab Association for Pharmacy Development and its conference (AIPC 2019). She is member of many scientific societies as (AAPS) and Alzheimer's Association (ISTAART). She is also an Editorial Board Member of many international Journals as Brain Disorder & Therapy, Acta Psychopathologica, EC Pharmacology and Toxicology as well as Organizing Committee Member and Chairperson at many international Conferences as the International Conference on Brain Disorders & Dementia Care, Canada (2017) and International Conference on Parkinson's Disease & Movement Disorders, USA (2017, 2018). She published more than 60 papers in reputed journals, supervised and discussed more than 90 PhD and MSc thesis and actively participated by workshop, oral and posters presentations at many international conferences especially on Dementia and Parkinson's disease and in the Alzheimer's Association International Conference (AAIC 2016, 2017). She has many appreciation certificates and certificate of best presentation award at 19th International Conference on Environmental Pollution and Pollution Control, London, UK (ICEPPC 2017). Now she is a Head of Pharmacology and Toxicology Department and Member of the Committee for the Promotion of Professors at Al-Azhar University, Egypt.
E-mail: azzamoro@gmail.com
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