THE EFFICACY OF SUPPLEMENTATION OF VITAMIN D3 ON THE ERADICATION RATES OF CLARITHROMYCIN-BASED TRIPLE THERAPY FOR HELICOBACTER PYLORI INFECTION

doi:10.4066/2249-622X-C5-015

THE EFFICACY OF SUPPLEMENTATION OF VITAMIN D3 ON THE ERADICATION RATES OF CLARITHROMYCIN-BASED TRIPLE THERAPY FOR HELICOBACTER PYLORI INFECTION

Joint Event on GLOBAL PHARMA SUMMIT & 2^nd International Conference on GASTROENTEROLOGY AND HEPATOLOGY
November 23-24 , 2018 | Bangkok, Thailand

Mohamed EL Shahawy

Al Azhar University, Egypt

Posters & Accepted Abstracts : Asian J Biomed Pharmaceut

DOI: 10.4066/2249-622X-C5-015

Abstract:

Background/Aim: Because of the emergence of antibiotic resistance and adverse drug reactions, the successful eradication rates with the clarithromycin-based triple therapy are falling. The aim of this study was to assess the effect of supplementation of 1,25-hydroxy vitamin D3 on the eradication rates of Clarithromycin-based triple therapy for Helicobacter pylori (H.pylori) infection. Methods: This study included 150 patients diagnosed with H.pylori gastritis using magnifying narrow-band imaging endoscopy (ME-NBI) supported by stool antigen test as a diagnostic gold standard. Serum 25-OH vitamin D levels was measured via Enzyme Linked Immune Sorbent assay (ELISA) method before starting eradication therapy. Patients were divided into two groups: Patiesnts in group A (n=75) received amoxicillin, clarithromycin, and esomeperazol for 2 weeks. Patients in group B (n=75) received 1,25-hydroxy vitamin D3 for 4 weeks, in addition to amoxicillin, clarithromycin, and esomeperazol for 2 weeks. Stool antigen test was performed 4 weeks after the end of therapy to check the eradication rates. The eradication rates were assessed using per-protocol (PP) and intention-to-treat (ITT) analysis. Results: Our results revealed that, eradication was achieved in 46 of 62 patients (74.19%) by PP and 46 of 75 (61.33%) by ITT analysis in group A while in group B , eradication was achieved in 60 of 68 patients (88.23%) by PP and 60 of 75 (80 %) by ITT analysis . The eradication rates in Group B was significantly higher than that of Group A (p= 0.012 in ITT analysis and p=0.029 in PP analysis). However, there were no statistically significant differences regarding serum 25-OH vitamin D level between these 2 groups and the mean 25-OH vitamin D level was 28.9±10.6 in group A and 28.3±9.8 in group B (p=0.268). Conclusions: Our results demonstrated that supplementing vitamin D3 to Clarithromycin-based Triple Therapy could provide an additional advantage for achieving significantly higher eradication rates for H. pylori infection. Keywords: Vitamin D3, Magnifying narrow band, Helicobacter pylori eradication

Biography:

PDF HTML