+44 1400 530055The D-dimer reference intervals in healthy term newborns
16th International Conference on PEDIATRICS HEALTHCARE
November 15, 2022 | Webinar
Zamin ?brahimhalilov, Safarova Sahila, Nilgün Altuntas
Ankara Y?ld?r?m Beyaz?t University, Turkey
Ankara Gazi University, Turkey
Scientific Tracks Abstracts : Curr Pediatr Res
Abstract:
Materials and methods: The research had been carried out in the obstetrics and gynecology clinic and neonatal outpatient clinic of a third level hospital. Healthy-term newborns aged between 1 and 28 days were enrolled in the study. Venous blood samples were collected from peripheral veins in all babies and D-dimer, prothrombin time, activated partial thromboplastin time and platelet counts were measured. Reference intervals for D-dimer in the neonatal period were determined using 2.5th and 97.5th percentile values. Results: A hundred and thirty-four newborns (71 boys, 63 girls) were enrolled in the study. Mean D-dimer levels of infants aged 1–28 days was 1.74 ± 1.88 mg/L (reference range; 0.25–2.81 mg/L). D-dimer levels were between 2.44 and 2.45 mg/L, 1.71–1.76 mg/L, 1.26–0.89 mg/L and 0.88–0.66 mg/L in the first, second, third and fourth week of life, respectively. D-dimer values inversely correlated with postnatal age (r:−0.3, p < 0.001). However, it remained above adult levels even in the last week. There was no statistically significant difference between the D-dimer levels of girls (1.93 ± 2.06 mg/L) and of boys (1.57 ± 1.71 mg/L). Discussion: In this study, D-dimer levels in the neonatal period were found to be higher than adult levels stated in the literature. D-dimer levels gradually decreased over time in the first month. It would be appropriate to use age-specific reference values in the evaluation of D dimer levels in the neonatal period. References 1. Hemostasis in newborns of smoking and nonsmoking mothers. P.E. Mercelina-Roumans et al, Am J Obstet Gynecol(1997) 2. Developmental hemostasis: relevance to hemostatic problems during childhood. M.M. Flanders et al, J Pedia(2006) 3. Pediatric reference intervals for seven common coagulation assays. M. Andrew, Semin Thromb Hemost(1995)
Biography:
Zamin ?brahimhalilov graduated at the age of 23 years from Azerbaijan medical faculty, Azerbaijan as a general practitioner. After 4 years of residency, he graduated from Ankara Y?ld?r?m Beyaz?t University medical faculty, department of pediatrics, Turkey. He is a Pediatrician and has 3 publications. He is currently working as a pediatrician in a private hospital.
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