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The Biological activities of group 10 schift base Dithiocarbamate compound Nanoparticle
2nd International Conferences on Nanotechnology & Chemistry
April 06-07, 2022 | Webinar
Felicia F. Bobinihi
Federal College of Education, Okene, Nigeria
Scientific Tracks Abstracts : J Pharm Chem Chem Sci
Abstract:
The increase in the outbreak of new infectious diseases coupled with the increase in drug resistance pathogens have aroused the interest of chemists in the quest for new and effective compounds with improved pharmacological potentials. The recent pandemic ravaging the whole World called corona virus disease (COVID-19), with new waves coming out periodically is a typical example. It is proposed that cocktail of drugs: antibiotics, anti-inflamatories and anticoagulants are the way forward to fight this dreadly virus because it is suspected from autopsies to be disseminated intravascular coagulation (Thrombosis). Schiff base compounds with the presence of an azomethine group –RC=NR’ play a central role in coordination chemistry through the O and N atoms’. When combined with the dithiocarbamate ligand, the presence of multisites on the dithiocarbamate moiety gives room for multiple interactions and this enhances their biological activities on different proteins and enzymes in medicinal applications. The group 10 metals with their diverse chemistry and important therapeutic applications especially in medicine when combined with dithiocarbamate ligands with excellent coordination ability produce compounds with diverse characteristic properties with improved pharmacological activities. From the direct M-S bond thermal decomposition results, the dithiocarbamate metal complexes have been utilized as single source precursors for the preparation of metal sulphides The biological activities of the prepared nanoparticles were studied, to determine the improved activities over the bulk complexes based on the small size dimensions and nanoparticle drug delivery system. The slight alteration in their structures lead to great quantitative and qualitative changes in their activities which was observed in the metal sulphides obtained as they yielded anisiotropic nanoparticles. These changes could be ascribed to differences in the decomposition profile in the solvothermal process used for the nanoparticles synthesis. The different nanoparticles displayed interesting optical and structural properties with the presence of the bridging and chelating organic ligands giving rise to monodispersed nanoparticles which acquire some important structural properties from the precursor compounds. An increased in antibacterial and antifungal activities was also observed.The compounds can therefore be considered as one of the proposed antibiotics in the coombination of drugs for the treatment of infectious diseases in this pandemic era.
Biography:
Felicia Bobinihi has completed her PhD degree from the North West University, South Africa. She is currently a senior lecturer at the Federal college of Education, Okene, Nigeria. She is working on inorganic and material synthesis, their processing and applications in various fields from where she has published some papers in international peer review journals.
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