Journal of Food Technology and Preservation

Supplementation with Glutamine Enhances the Effects of Low FODMAP Diet in Management of Irritable Bowel Syndrome

10^th International Conference on Food Science & Technology
February 07, 2022 | Webinar

Azita Hekmatdoost

Research Institute, ShahidBeheshti University of Medical Sciences, Iran

Posters & Accepted Abstracts : J Food Technol Pres

Abstract:

Background: Although irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders presenting to gastroenterologists, therapeutic strategies have not yet well established. Accordingly, we conducted a randomized, double-blind, placebo controlled, clinical trial to evaluate the possible superiority adding glutamine supplement to low fermentable oligo- di- monosaccharides and polyols (FODMAP) diet in patients with IBS Methods: Eligible adults were randomized to receive low FODMAP diet either with glutamine (15 gram/day) or placebo r 6 weeks. The primary end point was a reduction of ≥50% on the IBS Severity Scoring System (IBS-SSS). Secondary endpoints were changes in IBS symptoms and quality of life. Results: Fifty patients were enrolled in the study, while 22 participants completed the study protocol in each group. The glutamine group had significant changes in total IBSseverity score, dissatisfaction of bowel habit and interference with community function (58% reduction; p<0.001, 57% reduction; P <0.001, 51% reduction; p=.043, respectively). Improvement in IBS-severity score of more than 50% was observed in 18 of 22 participants (82%) in glutamine group, while it was only in 6 of 22 participants (27%) in control group. No serious adverse events were observed. Conclusions: Our findings indicate the superiority of adding glutamine supplementation to low FODMAP diet in amelioration of IBS symptoms, while confirming the beneficial effects of low FODMAP diet in IBS management.

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