STUDY ON CYTOTOXIC ACTIVITY OF SOME EXTRACTS OF VINCA ROSEA L. INTRODUCED TO WESTERN GEORGIA

STUDY ON CYTOTOXIC ACTIVITY OF SOME EXTRACTS OF VINCA ROSEA L. INTRODUCED TO WESTERN GEORGIA

International Conference on ANALYTICAL CHEMISTRY
November 21-22 , 2018 | Madrid , Spain

Vachnadze N, Vachnadze V, Mshvildadze V, Legoult J and Pichette A

TSMU I. Kutateladze Institute of Pharmacochemistry, Georgia

Posters & Accepted Abstracts : J Chem Tech App

Abstract:

Malignant cancer belongs to the number of the most widespread diseases in the world. As WHO forecast notifies number of victims of malignant cancer will be 2015 will die 9 million, 11,4 million in 2030. So mortality caused by the malignant tumors is presented disturbing statistical data. The object of our research were the alkaloids extracts obtained from aerial parts of Vinca rosea L. Cytotoxicity was assessed against A-549 (lung cancer cell line), DLD-1(colon adenocarcinoma cell line) and WS-1 (normal skin fibroblast cell line) cytotoxic activity was expressed inhibiting cell growth by 50% (IC50). Etoposide was used as positive control. Results: In vitro cytotoxic activities of extracts 1,2 were assessed against using resasurin reduction test, but extract 3 Hoechs test.

Biography:

Vachnadze N has completed her PhD at the age of 45 years from Tbilisi State Technical University, Georgia. She is a principal scientist of TSMU Iovel Kutateladze Institute of Pharmacochemistry. She has published more than 60 publications in reputed journals. She is a member of organizing committee of several international conferences and meetings.

E-mail: vachnadze_nina@yshoo.com

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