Study of the role of homocysteine in the initiation of a thrombophilic state in patients with severe coronavirus infection

Study of the role of homocysteine in the initiation of a thrombophilic state in patients with severe coronavirus infection

6^th Global Summit on Allergy and Immunology & 6^th International Conference on Clinical Hematology & Transfusion Medicine & 4^th World Congress on Infection Prevention and Control & 2^nd European Congress on Virology and Immunology
April 29, 2022 | Joint Webinar

Berger Inna

Republican Specialized Scientific and Practical Medical Center of Hematology, Uzbekistan

Scientific Tracks Abstracts : Microbiology: Current Research

Abstract:

The study was conducted at the specialized multidisciplinary infectious diseases clinic for the treatment of coronavirus infection. The material was the blood of 60 patients in the intensive care units of the clinic with severe and extremely severe COVID-19, with lung damage from 30 to 90%. The control group consisted of 15 apparently healthy people, with no signs of thrombosis at present and in history. The study of hemostasis parameters was carried out on an ACL-TOP 350 coagulometer manufactured by International Laboratory (USA) and reagents from HemosIL (USA). In parallel, with shifts in the coagulation link of hemostasis, increased platelet aggregation was observed, which may be the result of an increase in homocysteine in the blood and its damaging effect on the vascular endothelium. Since it is known that homocysteine is able to “loosen” the endothelium, as a result of which platelets adhere to the damaged layers and the process of thrombus formation begins. Laboratory data on homocysteine levels in patients with coronavirus infection.

Biography:

Berger Inna received her PhD in Medical Sciences in 2020 from the Tashkent Medical Academy; in 2022 she received a senior researcher degree and is the head of the scientific department of hemostasis pathology at the Republican Specialized Scientific and Practical Medical Center for Hematology. He has more than 60 publications in local and foreign journals, has patents and is the author of a monograph on thrombosis.

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