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SPECIFIC FEATURES OF IMMUNE COMPLEXES IN PATIENTS WITH SARCOIDOSIS AND PULMONARY TUBERCULOSIS
2nd Global Summit on IMMUNOLOGY AND CANCER THERAPY
May 22-23, 2019 | Rome, Italy
Starshinova Anna, Zinchenko Yu, Filatov M, Landa S, Burdakov V and Yablonskiy P
Ministry of Health of the Russian Federation, Russia St. Petersburg State University, Russia
Posters & Accepted Abstracts : Immunol Case Rep
Abstract:
Background: Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping and therefore,
a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis
due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient
with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of
tuberculosis.
Materials & Methods: A prospective study was conducted with two groups of patients: Group I (n=50)-patients
with pulmonary sarcoidosis established according to standard criteria; group II (n=28)-patients with pulmonary
tuberculosis with bacterial excretion. The control group (n=24) was presented by healthy subjects. The
examination complex included x-ray, bacteriological, immunological (Mantoux test with two TE and TB.SPOT
test) and histological methods. All patients and healthy subjects were assessed for immune complexes with
the use of the dynamic light scattering (DLS) method and adding of “healthy lung tissue extract” antigens and
specific tuberculosis antigens ESAT-6 and SFP-10 in vitro.
Results: Significant differences were found in determining of specific immune complexes in patients with pulmonary
sarcoidosis and pulmonary tuberculosis. Registration of specific immune complexes formation with
“healthy lung tissue extract” in 100% cases may indicate the autoimmune nature of sarcoidosis. The absence
of the immune complexes formation in response to ESAT-6/SFP-10 antigens can be used for the differential
diagnosis of two diseases. The diagnostic significance of the DLS method was 100% for sarcoidosis and 92.2%
for tuberculosis.
Conclusions: The data obtained in the study allows not only understanding the etiology of sarcoidosis but also
obtaining new criteria for the differential diagnosis of tuberculosis and pulmonary sarcoidosis.
Biography:
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