Risk assessment by chronic toxicity to exposure of magnesium at a renal level in rats of the species Rattus Norvegicus

doi:10.4066/2249-622X-C4-012

Risk assessment by chronic toxicity to exposure of magnesium at a renal level in rats of the species Rattus Norvegicus

Joint Event on 8^th World Congress on Chemistry and Organic Chemistry & International Conference on Biomedicine & Pharmacotherapy
October 22-23, 2018 | Frankfurt, Germany

Giancarlo Mendez Agreda

Universidad Nacional Mayor de San Marcos, Peru

Posters & Accepted Abstracts : Asian J Biomed Pharmaceut Sci

DOI: 10.4066/2249-622X-C4-012

Abstract:

A histological examination from kidneys, specifically at the level of renal cortex and medullary thick ascending limb of Henle’s loop, in a group of albino rats of the species Rattus norvegicus Holtzman strain, to which were administered orally magnesium chloride Ad. Libitum at concentrations below the LD50 but above the RDA, showed sublethal damage evidenced by a slight swelling that encompassed the medullary and cortical area in the study group compared with the control group. In addition to this, biochemical parameters in blood and urine were also affected, which has demonstrated that the consumption above the RDA and without the guidance of a health professional is detrimental to long-term health.

Biography:

Giancarlo Mendez Agreda has completed his MSc at the age of 30 years old at University of Turku, Finland. He is a pharmacist graduated from Universidad Nacional Mayor de San Marcos (Peru). He also counts with experience at pharmaceutical industry as a formulator.

E-mail: gianmenag@gmail.com

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