+441518081136Recent advancements in cancer genomics
International Conference on Oncology and Cancer Therapeutics
October 30- November 01, 2017 | Chicago, USA
Shrikant M Mane
Yale Center for Genome Analysis, USA
Scientific Tracks Abstracts : J Med Oncl Ther
Abstract:
The Yale Center for Genome Analysis (YCGA) is a stateof-the-art DNA Sequencing Center launched in 2010 to provide an open access centralized facility for services, equipment and expertise required for carrying out largescale sequence analysis studies. Our group foresaw scientific opportunities for the development and use of exome sequencing in Mendelian genetics and was the first to develop the method for exome capture on the NimbleGen/ Roche platform. We were also the first to demonstrate the biological utility of exome sequencing for clinical diagnostic applications. Currently, YCGA is a part of the NHGRI supported Yale Center for Mendelian Genomics that uses NGS and computational approaches to discover the genes and variants that underlie Mendelian conditions. In the last four years, the use of next-gen sequencing has led to the publications of >375 articles in peer reviewed journals, including >40 in high profile journals such as Science, Nature, Cell, New England Journal of Medicine and Nature Genetics reporting new variants in various disorders, including cancer, hypertension, autism, several types of cancers, Gaucher disease, skin disorders, and cortical malfunctions, all using exome analysis. The presentation will focus on recent biomarker discoveries in cancer and clinical applications.
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