+1 (629)348-3199Protocatechuic acid loaded chitosan coated iron oxide nanoparticles for cancer therapy
Global Meet on Nanomedicine & Healthcare
November 06-07, 2017 | New Orleans, USA
Farahnaz Barahuie
Sistan and Baluchestan University, Iran
Posters & Accepted Abstracts : Biol Med Case Rep
Abstract:
Iron oxide nanoparticles (FNPs) were synthesized by coprecipitation method, followed by coating with chitosan (CS) biopolymer and used as a nanocarrier for efficient delivery of anticancer agent protocatechuic acid (PA). The Fourier transform infrared spectra revealed that the FNPs nanoparticles could be successfully coated with CS polymer and PA as an active anticancer drug. The magnetic measurements showed that the designed nanocarrier and protocatechuic acid-chitosan-iron oxide nanocomposite (PACS-FNP) were superparamagnetic while the release of PA from PA-CS-FNP nanocomposite was found to be in a sustained manner and significantly lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The spherical shape of nanosized FNPs and PACS-FNP was observed by Transmission Electron Microscopy (TEM) and loading of PA in the PA-CS-FNP nanocomposite was estimated to be about 11.3 %. In addition, PA-CS-FNP nanocomposite showed higher inhibitory effect to cancer cell growth than free PA, without affecting normal fibroblast (3T3) cell growth.
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