Primary antibiotics resistance of Helicobacter pylori isolated from Peptic Ulcer children at National Pediatric Hospital, Hanoi, Vietnam

Primary antibiotics resistance of Helicobacter pylori isolated from Peptic Ulcer children at National Pediatric Hospital, Hanoi, Vietnam

2^nd World Congress on Pediatrics and Clinical Pediatrics
June 12-13, 2019 | Edinburgh, Scotland

Thi Ut Nguyen, Thanh hai le, Thu Hien pham and Thi Bich Ngoc Hoang

National Pediatric Hospital, Vietnam

Posters & Accepted Abstracts : Curr Pediatr Res

Abstract:

Statement of the Problem: Helicobacter pylori (H. pylori) is the major cause of peptic ulcer disease (PUD) in children. Treatment of H. pylori induced PUD is challenging due to antibiotics resistance. The objective of this study is to evaluate the prevalence of antibiotic resistance in H. pylori strain isolated from PDU children in National Pediatric hospital in 2017 in Vietnam. Methodology & Theoretical Orientation: 165 children had symptoms of gastro-duodenal disease with no history of eradication of H. pylori, were included in the present study. By gastric endoscopy, we performed biopsy, and dyed H. pylori shed for histopathology,. We conduct H. pylori culture to examine antibiotic resistance of H. pylori to clarithromycin, levofloxacin, amoxicillin, tetracycline and metronidazole. were performed according to a standardized protocol using Etest strips The study was conducted from January 2017 through December 2017 in National hospital of Pediatrics, Hanoi, Vietnam. Findings: We observed 163 strains (98.8%)with primary antibioticresistant H. pylori. Resistance to clarithromycin was the most predominant with the highest proportion of 97%. Resistance to amoxicillin, metronidazole, levofloxacin and tetracycline were 51.5%, 66.1%, 9.7% and 0.6 %, respectively. Co-resistance to 2 antibiotics was observed among 64.8% forclarithromycin and metronidazole, and 31.5% for amoxicillin and metronidazole. Triple resistance to amoxicillin, clarithromycin, and tetracycline was as low as 0.6%. Since primary antibiotic resistance of H. pylori children on peptic ulcers are common, it is necessary to the use antimicrobial susceptibility test before prescribing antibiotics in order to improve the effectiveness of H. pylori eradication.

Biography:

Thi Ut Nguyen is a pediatrician. She is working as gastroenterologist in Gastroenterology department of the National Pediatric Hospital. She has conducted several studies on Helicobacter pylori antibiotics resistance and virulence of gastritis and peptic ulcer among children.

E-mail: nguyenvuthuyduong2003@gmail.com

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