Journal of Food Technology and Preservation

Malnutrition, Body Mass Index and N-terminal pro-Brain Natriuretic Peptide in hemodialysis patients

10^th International Conference on Food Science & Technology
February 07, 2022 | Webinar

Ducros J

University Hospital, France

Posters & Accepted Abstracts : J Food Technol Pres

Abstract:

Uremic malnutrition also called protein energy wasting (PEW), is a common problem in patients with end stage renal disease undergoing hemodialysis (HD). This syndrome has been associated with, morbidity and mortality. Association between malnutrition and N-terminal pro-brain natriuretic peptide (NT-proBNP), a predictive factor of cardiac events and mortality has been reported. In addition, inverse relationships between body mass index (BMI) and circulating levels of NTproBNP have been demonstrated. We evaluated the association between NT-proBNP, BMI and malnutrition in a sample of Afro-Caribbean HD patients. Malnutrition was identified according to the International (ISRMN) definition and one component in each of the 4 categories of the wasting syndrome were retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m2, creatininemia ≤ 818 μmol/L/ m2 and nPCR≤ 0.8 g/kg/day. NT-ProBNP was assessed using a chimiluminescence immunoassay, at the start of dialysis. In 207 patients (mean age: 64 years +/-13), NT-ProBNP ranged from 125 to 33 144 pg/ mL. The major comorbidities were hypertension (90%), diabetes (41.5%), obesity (26.5%) and PEW (at least three components) was found in 16.9%. Log NT-ProBNP was negatively correlated with BMI (r = - 0.19, P = 0.005) and also with left ventricular ejection fraction. Patients with high NT-ProBNP levels (≥ 6243 pg/mL) had higher frequencies of malnutrition (≥3 factors) (34.6 % vs 11.0 % in those with NT-ProBNP levels < 6243 pg/mL; P < 0.001), including BMI ≤ 23 Kg/m2 (55.8 % vs 29.0 %; P < 0.001) and mean BMI was 23.8 ± 5.2 vs 26.9 ± 6.9 Kg/m2 ; P = 0.004. In HD patients, several parameters could be involved in the association between NT-proBNP and malnutrition, including inflammation and inadequate protein and caloric intake, that could lead to low BMI. NT-proBNP levels must draw attention to cardiac function but also to nutritional status.

PDF HTML