+441518081136Investigation of the anticancer activity of electron-deficient organometallic complexes
Joint Event on International Conference on Organic and Inorganic Chemistry & 8th World Congress on Green Chemistry and Technology
February 18-19, 2019 | Paris, France
Maria Azmanova
University of Bradford, United Kingdom
Posters & Accepted Abstracts : J Ind Environ Chem
Abstract:
Ruthenium and osmium complexes are considered as an attractive alternative to platinum-based anticancer drugs since the latter have major disadvantages such as high toxicity, low selectivity and chemoresistance. We have recently developed strong interest in electron-deficient ruthenium and osmium complexes and investigated their anticancer properties. The design of such molecules, with possibilities of altering their activity by introducing different ligands, is of a great importance, as well as unveiling their mechanisms of action. Their cytotoxicity towards human colon HCT116 p53+/+ and HCT116 p53-/- cancer cell lines has been investigated, including the effects these precious metal complexes have on different genes involved in DNA damage responses, cell cycle arrest, and apoptosis. Their mechanism of action has been explored further by cell cycle analysis and investigation of the oxidative stress they induce in cells.
Biography:
E-mail:
M.Azmanova@bradford.ac.ukPDF HTML