Journal of Biotechnology and Phytochemistry

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Intracellular delivery of biomacromolecules

7th World Congress on Chemistry
November 13-15, 2017 Athens, Greece

Nathalie Lavignac

University of Kent and Greenwich at Medway, United Kingdom

Posters & Accepted Abstracts : J Biotech and Phyto

Abstract:

Efficient delivery of non-permeant therapeutic agents with intracellular therapeutic targets is challenging. Over the years, methods using viral and/or non-viral vectors have been developed. Synthetic polymers, often considered a safer alternative, may be tailored to improve cytoplasmic access and modulate cell specific targeting. Poly(amidoamine)s (PAAs) are a family of synthetic functional polymers developed for use as polymer therapeutics.They are synthesized by Michael addition polymerization, are generally water soluble and display pH-dependent membrane activity. We will discuss the biological rational for the development of these polymers and review their application for the delivery of macromolecular drugs (e.g. proteins, oligonucleotides).

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