+1 (629)348-3199Impact of human cytomegalovirus infection on survival of patients with Ovarian Cancer
29th International Conference on Nursing Education and Research
December 05-06, 2019 | Dubai, UAE
MinYin and Ai-PingChen
Qingdao University, China
Posters & Accepted Abstracts : J Intensive Crit Care Nurs
Abstract:
Human cytomegalovirus (HCMV) has been detected in various types of tumors. We studied the prevalence of HCMV in ovarian cancer and its relation to clinical outcomes. Paraffin-embedded tissues obtained prospectively from 60 patients with ovarian cancer, 30 patients with benign ovarian cystadenoma and 10 patients with normal ovarian tissue were analyzed for expression of HCMV immediateearly protein (IE) and HCMV tegument protein (pp65) by immunohistochemistry. Extensive HCMV-IE protein expression was detected in 73%of ovarian cancers and 23% of benign tumors; pp65 was detected in 65% ofovarian cancers and 13% of benign tumors. A higher grade of HCMV infection was associated with higher stage of disease. Extensive HCMVpp65 expression was associated with shorter median overall survival than focal expression (37 versus 45 months, P=0.04). At study closure, 55% of ovarian cancer patients with focal pp65 expression were alive versus 28% of patients with extensive pp65 expression (P=0.03). Thus, HCMV proteins are detected at different levels in ovarian tumors and benign cystadenomas. Ovarian cancer patients with focal HCMVpp65 expression in their tumors lived longer, highlighting a need for in-depth studies of the oncomodulatory role of HCMV in ovarian cancer.
Biography:
E-mail:
1239096840@qq.comPDF HTML