+441518081136Femtomedicine in cancer: Discovery of new antitumor molecules for natural targeted chemotherapy and radiotherapy of cancers
International Conference on Oncology and Cancer Therapeutics
October 30- November 01, 2017 | Chicago, USA
Qing-Bin Lu
University of Waterloo, Canada
Scientific Tracks Abstracts : J Med Oncl Ther
Abstract:
The conquest of cancer continues to pose great challenges to medical science. There is a compelling need for innovative cancer research integrating biomedical sciences with physical sciences in order to ultimately conquer cancer. Femtomedicine (FMD), which integrates femtosecond timeresolved laser spectroscopy with biomedical sciences, was recently coined to advance fundamental understanding and therapies of human diseases notably cancer. Our studies in FMD have led to the discoveries of the reductive damaging mechanism in DNA and living cells and the molecular mechanisms of action of existing anti-cancer agents. These have offered unique opportunities to develop new effective drugs for high-performance therapy of cancer. We have particularly found a new class of non-platinum-based anticancer compounds (called FMD compounds) for natural targeted chemotherapy and radiotherapy of a variety of cancers, e.g., cervical cancer, ovarian cancer, head and neck cancer, breast cancer, lung cancer, etc. Treatments of various cancer cells in vitro and in vivo mouse xenograft models with FMD compounds led to effective chemotherapy and enhanced radiotherapy, while the compounds themselves induced no or little systemic and radiation toxicity. These compounds are therefore a new class of potent antitumor agents that can be translated into clinical trials for targeted chemotherapy and radiotherapy of multiple types of cancer. The results also show that FMD can bring breakthroughs in understanding fundamental biological processes and lead to advances in cancer therapy. This presentation will discuss some progress in this new frontier—FMD in Cancer.
Biography:
Qing-Bin Lu received his PhD from the University of Newcastle, Australia, and completed his postdoctoral positions at Rutgers University, University of Sherbrooke and California Institute of Technology. He is a full professor and a University Research Chair at the University of Waterloo, Canada. His research in femtomedicine (FMD), which fuses ultrafast laser techniques with biomedical sciences to advance fundamental understanding and treatment of human diseases, notably cancer, has led to the discoveries of novel anti-cancer agents for targeted chemotherapy and radiotherapy of multiple types of cancers. He has published over 50 papers in prestigious journals.
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