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Factors associated with the implementation of an improved community health fund in the Ubungo Municipality Area, Dar es Salaam Region, Tanzania
19th International Conference on CANCER AND CANCER THERAPY
December 07, 2022 | Dubai, UAE
Ehsan Karimi
Islamic Azad University, Iran
Posters & Accepted Abstracts : J Can Clinical Res
Abstract:
Background: This research was performed to synthesize nanophytosomes-loaded High Phenolic Fraction (HPF) from Juniperus polycarpos fruit extract and investigate its antiproliferation effects against breast cancer in mice model. Results: The Nanophytosomes-loaded HPF from Juniperus Polycarpos fruit extract was synthesized. The mice trial was conducted to determine the possible toxic effects of the synthesized nanophytosomes. The anticancer, pro-apoptotic, and antioxidative activities of the nanophytosomes were determined. The nanophytosomesloaded HPF had a spherical structure with a size of 176 nm and a polydispersity index coefficient of 0.24. The in-vivo study manifested that nanophytosomes-loaded HPF significantly improved weight gain and food intake compared to the negative control group (p<0.05). The nanophytosomes-loaded HPF significantly enhanced the expression of bax (3.4-fold) and caspase-3 (2.7-fold) genes but reduced bcl2 (3.6-fold) gene expression in tumor cells. The average tumor size was significantly decreased in mice treated with nanophytosomes-loaded HPF (p<0.05). The expression of GPX (2.3-fold) and SOD (2.7-fold) antioxidants in the liver of mice supplemented with nanophytosomesloaded HPF was significantly developed compared to the negative control (p<0.05). The nanophytosomes-loaded HPF did not show toxicity on normal cells. Conclusion: Our results indicated that nanophytosomesloaded HPF might be a potential anticancer agent for the breast cancer treatment.
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