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Extensive tumour profiling in primary neuroendocrine breast cancer cases as a role model for personalized treatment in rare and aggressive cancer types
19th International Conference on CANCER AND CANCER THERAPY
December 07, 2022 | Dubai, UAE
Dorthe Schaffrin-Nabe
Praxis fur Hamatologie und Onkologie, Germany
Scientific Tracks Abstracts : J Can Clinical Res
Abstract:
Neuroendocrine Breast Cancer (NEBC) is a rare entity accounting for <0.1% of all breast carcinomas and <0.1% of all neuroendocrine carcinomas. In most cases treatment strategies in NEBC are empirical in absence of prospective trial data on NEBC cohorts. Herein, we present two case reports diagnosed with anaplastic and small cell NEBC. After initial therapies failed, comprehensive tumor profiling was applied, leading to individualized treatment options for both patients. In both patients, targetable alterations of the PI3K/ AKT/mTOR pathway were found, including a PIK3CA mutation itself and an STK11 mutation that negatively regulates the mTOR complex. The epicrisis of the two patients exemplifies how to manage rare and difficult to treat cancers and how new diagnostic tools contribute to medical management. Recent Publications 1. Schaffrin-Nabe, Dörthe et al. “Case Report: Extensive Tumor Profiling in Primary Neuroendocrine Breast Cancer Cases as a Role Model for Personalized Treatment in Rare and Aggressive Cancer Types.” Frontiers in medicine vol. 9 841441. 3 Jun. 2022, doi:10.3389/fmed.2022.841441 2. Schaffrin-Nabe, Dörthe et al. “The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia.” Oncology research and treatment vol. 38,10 (2015): 489-95. doi:10.1159/000440636
Biography:
Dorthe Schaffrin-Nabe is an Experienced Professional in Praxis für Hämatologie und Onkologie in Bochum, Germany.
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