+441518081136Evaluating the combined efficacy of oral isotretinoin and topical tacrolimus versus oral finasteride and topical tacrolimus in frontal fibrosing alopecia - A randomized controlled trial
7th World Congress on Pharmacological and Toxicological Studies
December 14, 2022 | Webinar
Amir Mohammad Beyzaee
Mazandaran University of medical sciences, Iran
Scientific Tracks Abstracts : J Pharmacol Ther Res
Abstract:
Objective: Treatment of frontal fibrosing alopecia (FFA) is complicated and challenging. In this study, we evaluated the efficacy of combining topical tacrolimus with isotretinoin versus finasteride in patients with FFA.Methodology: Thirtyone patients with FFA were divided randomly into two groups. Therapeutic regimen of the first group (group A, n = 16) was isotretinoin and tacrolimus (Capsule isotretinoin 20 mg daily and topical tacrolimus 0.1% BD). The second group (group B, n=15) was given finasteride and tacrolimus (Tablet finasteride 2.5 mg daily and topical tacrolimus 0.1% BD). Patients were treated and followed up periodically for 12 weeks. Evaluation of the treatment efficacy was based on Patient Global Assessment and Physician Global Assessment scales. Objective evaluation was based on improving the severity of skin lesions by viewing serial images taken from the affected areas. Results: Physician Global Assessment (PGA) was significantly better in the group A as compared with the group B at 4 weeks (p=0.038). Physician satisfaction in the group A was better than the group B at 12 weeks, but this was not statistically significant (p > 0.05). Patient Global Assessment and patient satisfaction in the group A was better than the group B at 8 and 12 weeks, but it was not statistically significant(p > 0.05). Conclusion: Although both therapeutic regimens were effective in the treatment of FFA, treatment with tacrolimus and isotretinoin is significantly more effective than tacrolimus and finasteride. Recent Publications 1. Amir Mohammad Beyzaee ,Ghasem Rahmatpour Rokni & Anant Patil Comparison of the efficacy of carboxytherapy versus fractional CO2 laser therapy for the treatment of Periorbital Dark Circles: A Randomized Clinical Trial Journal of Cosmetic Dermatology 2022;00:1–5. 2. Amir Mohammad Beyzaee, Kobra Gerizade Firozjaii & Masomeh Bayani Clinical features and para-clinical findings of cryptococcal meningitis in the North of Iran during 2011-19 Curr Med Mycol. 2020 Dec; 6(4): 41–46. 3. Amir Mohammad Beyzaee, Farzad Masiha & Hossein Karami Digital Clubbing and Hodgkin Disease in Children: A Case Report and Review of Literature Journal of pediatrics review July 2021, Volume 9, Issue 3, Number 23.
Biography:
Amir Mohammad Beyzaee. I am a GP, graduated from Mazandaran University of medical sciences. I have been working in dermatology field for the last 3 years. Also, i have made efforts in researching, writing review articles, clinical trials, and peer-reviewing the articles.
PDF HTML