Insights in Nutrition and Metabolism

Effect of jali extract (coixlacrimajobi l) on the mice with diabetes mellitus blood glucose in vivo

International Conference on VITAMINS, NUTRIGENOMICS & MALNUTRITION
September 15-16, 2017 | Dallas, USA

Nanny, Kathena, Ingrid and Yanti

Jaya Catholic University, Indonesia

Scientific Tracks Abstracts : Insights Nutr Metab

Abstract:

Background: Type 2 diabetes mellitus (DM) is a chronic disease marked by the elevation of blood glucose. There are many factors that can cause type 2 DM, such as genetics, poor dietary habits, life style, and many more. Choices of the correct food ingredients can help control blood glucose in patients with type 2 DM.Jali (CoixLacrimaJobi L) is a tropical grain that belongs to thePoaceaefamily or flowering plants (grass). In a study of twelve antidiabetic plants, Jali has been demonstrated to have theantidiabetic effects that can reduce blood glucose in patients with type 2 DM.8 Purpose: To determine the effect of Jali extract on the mice’s blood glucose with diabetes mellitus. Methods: An experimental studyhas been conducted in five groups of ten male mice and eachhas beenadministratered with 10 mg of jali extract and 50 mg/kg in aquadest daily for 30 days. The groups are (1) negative control (without aloxan and aqudest), (2) positive control (with injections of aloxan and aquadest), (3) glibenclamide (GC)-50 standard (with injections of aloxan and GC 50 mg/kg), (4) polysaccharide extract (BSF)-10 (induction of aloxan and BSF 10 mg/kg), and (5) BSF-50 (induction of aloxan and BSF 50 mg/ kg). From each animal, serum blood glucose was recorded and analized before the experiment started as the baseline, on the 15th, and 30th days, these mice are then sacrificed by euthanasia on the 30th day. The results demonstrated that jali has the effect of reducing mice’s serum blood glucose in 30 days and it shows the efficacy of jali polysaccharide fraction as an antidiabetic agent. Results: The use of jalipolysaccharide extract 50mg/kg body weight significantly reduce blood glucose. Conclusion: The use of jali extract as a natural antidiabetic agent.

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