+441518081136Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for schizophrenia
Joint Event on 2nd International Conference on Wound Care, Tissue Repair and Regenerative Medicine & World Congress on Microbiology & Applied Microbiology
February 21-22, 2019 | Paris, France
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
Posters & Accepted Abstracts : J Trauma Crit Care
Abstract:
There is increasing evidences that favour the prenatal
beginning of schizophrenia. These evidences point toward
intra uterine environmental factors that act specifically during
the second pregnancy trimester producing a direct damage of
the brain of the fetus. The current available technology doesn’t
allow observing what is happening at cellular level since the
human brain is not exposed to a direct analysis in that stage
of the life in subjects at high risk of developing schizophrenia.
Methods: In 1977, we began a direct electron microscopic
research of the brain of fetuses at high risk from schizophrenic
mothers in order to finding differences at cellular level in
relation to controls.
Results: In these studies we have observed within the nuclei of
neurons the presence of complete and incomplete viral particles
that reacted in positive form with antibodies to herpes simplex
hominis type I [HSV1] virus and mitochondria alterations.
Conclusion: The importance of these findings can have practical
applications in the prevention of the illness keeping in mind
its direct relation to the aetiology and physiopathology of
schizophrenia. A study of the gametes or the amniotic fluid
cells in women at risk of having a schizophrenic offspring
is considered. Of being observed the same alterations that
those observed previously in the cells of the brain of the
studied foetuses, it would intend to these women in risk of
having a schizophrenia descendant, previous information
of the results, the voluntary medical interruption of
the pregnancy or an early anti HSV1 viral treatment as
preventive measure of the later development of the illness.
Biography:
E-mail:
segundo@infomed.sld.cuPDF HTML