+44-1518-081136Development of new biodegradable polymers for selected biomedical applications
7th International Conference on MATERIALS SCIENCE AND ENGINEERING
November 14, 2022 | Webinar
Hend Behour
Alexandria University, Egypt
Scientific Tracks Abstracts : Mater Sci Nanotechnol
Abstract:
High molecular weight biodegradable amphiphilic multiblock copolymers, formally poly(ether-ester-urethane)s were synthesized by condensation polymerization of PCL diol and PEG segments with 1,6-hexa methylen diisocyanate as coupling agent in the presence of dibutyltin dilaurate as catalyst. Different stoichiometric ratios of the hydroxyl end groups and isocyanate functionalities were utilized to produce copolymers with various characteristics. FT-IR, 1H-NMR, and GPC confirmed the chemical composition and the molecular weight of the formed multiblock copolymers. The crystal structure of the copolymers was studied using DSC, TGA, and WAXD. The contact angle measurements allowed correlating the hydrophilicity of the polymer surface to the polymer composition produced. The prepared multiblock copolymers were explored for the fabrication of biodegradable nano/ microfibrous scaffolds using the electrospinning technique. The ultrafine fibers developed were characterized for size and morphology using scanning electron microscopy. They were investigated as a dual function cell regeneration and drug delivery scaffold for selected biomedical applications. The scaffold was loaded with chlorhexidine to confer antimicrobial activity, of importance in applications such as wound healing. Chlorhexidine-eluting ultrafine fibers were characterized using IR and DSC. Ultrafine fibers with modulated properties controlled the release of chlorhexidine for more than 6 weeks.
Biography:
Hend Behour got her Bachelor degree of Science from Alexandria University at Special Chemistry with a final grade of very good. She has a master degree at Materials Science with grade point average of B+. She has enrolled in PhD program at Materials Science as well. She had given an oral presentation entitled "Chlorohexidine Nanofibers for Antimicrobial Biomedical Applications" in international conference organized by Arab Society of Materials Science (ASMS). She has also attended Drug Delivery summer school offered by Summer University DTU in 2018.
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