+44-1518-081136DECELLULARIZED HYALINE CARTILAGE GRAFT (DLHCG) FOR CARTILAGE REPAIR
3rd International Conference on BIOMATERIALS, CELLULAR AND TISSUE ENGINEERING
June 19-20, 2019 | Dublin, Ireland
Dong-An Wang
City University of Hong Kong, China
Keynote : Mater Sci Nanotechnol
Abstract:
In this study, author has developed a continuous methodology to directly set up a scaffold-free macro-scaled three-dimensional living hyaline cartilage graft (LhCG) with the aid of a biomaterial-based interim scaffolding system. The practical performance of decellularized LhCG (dLh- CG) is evaluated in the knees of large animal models with full-thickness chondral defects beyond critical sizes for six months. Hyaline cartilage based neo-tissue fulfills the desired in situ reconstruction. LhCG is also employed as an engineered biomimetic/pathological tissue platform for anti-arthritis drug evaluation in vitro. Arthritic disease models are created with LhCG by replicating the inflammatory environment of an arthritic joint via co-culturing LhCG with lipopolysaccharide (LPS)-activated macrophages, after which the accuracy of this model for in vitro drug-testing was validated using a popularly applied non-steroidal anti-inflammatory drug (NSAID). The results suggest that this new arthritic model is able to adequately mimic the native arthritic cartilage and is suitable to be used as an in vitro model for predicting native cartilage response to drug treatment.
Biography:
Dong-An Wang is a Professor of Biomedical Engineering in City University of Hong Kong. His research interests include biomaterials, tissue engineering and gene delivery. He has done significant research work in his research areas and published over 100 high quality journal papers including nature materials, advanced functional materials and biomaterials etc. He has been often invited as a theme Editor and Reviewer for a number of top journals. He has been conferred with various research/academic awards.
E-mail: dwang229@cityu.edu.hk
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